Vonoprazan Impurity 214 CAS 876062-39-4
| CAS No. | 876062-39-4 |
| Molecular Formula | C12H16BFO2 |
| Molecular Weight | 222.06 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Vonoprazan Impurity 214 (C12H16BFO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO supplies Vonoprazan Impurity 214 (CAS 876062-39-4), a pharmacopoeial impurity reference standard (molecular formula C12H16BFO2, MW 222.06 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Vonoprazan Impurity 214 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H16BFO2 |
| Molecular Weight | 222.06 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
Related Vonoprazan Standards
- Vonoprazan Impurity 306 (CAS CATO-C4X-1020306)
- Vonoprazan Fumarate Impurity 60 (CAS CATO-C4X-102060)
- Vonoprazan Fumarate Impurity 62 (CAS CATO-C4X-102062)
- Vonoprazan Fumarate Impurity 7 (CAS 1240948-72-4)
- Vonoprazan Fumarate Impurity 31 (CAS 2169267-53-0)
- Vonoprazan Impurity N27 (CAS 24367-50-8)
- Vonoprazan Impurity 261 (CAS CATO-C4X-1020261)
- Vonoprazan Impurity 283 (CAS CATO-C4X-1020283)
Recommended Standards
- N-(5-Bromo-1,3,4-thiadiazol-2-yl)acetamide (CAS 55114-97-1)
- 3,5-Dichloro-4-fluorophenyl isothiocyanate (CAS 1027513-82-1)
- Methyl 5-Bromothiazole-4-carboxylate (CAS 913836-22-3)
- 3,5-Dichloro-1-(tetrahydro-2H-pyran-2-yl)-1H-1,2,4-triazole (CAS 1088834-41-6)
- Olopatadine Impurity 31 (CAS CATO-C4X-171831)
- Mirogabalin Impurity 129 (CAS CATO-C4X-2924129)
- Oseltamivir Impurity 254 (CAS CATO-C4X-1720254)
- 1-(3-Morpholinopropyl)-1H-indol-4-amine (CAS 1021425-59-1)
- 3-nitro-4-pyrrolidin-1-ylbenzaldehyde oxime (CAS 329695-69-4)
- Acetochlor (CAS 123113-74-6)
- 1-(2,6-Dimethylphenyl)-1H-imidazole-4-carboxamide (CAS 1427013-56-6)
- Pigment Red 49:2 (CAS 1103-39-5)
- 2-Amino-2-(3,5-bis(trifluoromethyl)phenyl)acetic acid (CAS 261762-33-8)
- MOTS-c Peptide (CAS 1627580-64-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com