2-Hydroxy-2-methylbutyroyl chloride CAS 876944-75-1
| CAS No. | 876944-75-1 |
| Molecular Formula | C5H9ClO2 |
| Molecular Weight | 136.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 2-Hydroxy-2-methylbutyroyl chloride (CAS 876944-75-1), a certified reference material (molecular formula C5H9ClO2, MW 136.58 g/mol) for analytical method development and quality control.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, 2-Hydroxy-2-methylbutyroyl chloride is typically white to off-white liquid. Its solid-state physicochemical attributes — including a molecular weight of 136.58 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H9ClO2 |
| Molecular Weight | 136.58 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
Related Hydroxy Standards
- 3-Hydroxy-1,5-dimethyl-1H-pyrrole-2-carbonitrile (CAS 1881288-66-9)
- (R)-2-Hydroxy-2-(1-methyl-1H-pyrrol-2-yl)acetonitrile (CAS 290374-40-2)
- 3-Hydroxy-4-methylbenzaldehyde (CAS 57295-30-4)
- 4-Hydroxy-2-methylbenzaldehyde (CAS 41438-18-0)
- 5-Hydroxy-2,3-dihydrobenzofuran (CAS 40492-52-2)
- 2-hydroxy-1-phenyl-ethanon (CAS 582-24-1)
- 3-Hydroxy-2-methylbenzaldehyde (CAS 90111-15-2)
- 3-Hydroxy-5-methylbenzaldehyde (CAS 60549-26-0)
Recommended Standards
- 2-(Propan-2-yloxy)acetyl chloride (CAS 56680-71-8)
- 3-chloro-1,2,4-triazin-5-amine (CAS 57857-38-2)
- 2-(Chloromethyl)-2-methyl-1,3-dioxolane (CAS 4469-49-2)
- 3-Ethoxypropanoyl chloride (CAS 49775-37-3)
- 2-(Thiomethyl)phenylzinc iodide 0.5 M in Tetrahydrofuran (CAS 308796-24-9)
- [1,3-Bis(2,4,6-trimethylphenyl)imidazolidin-2-ylidene)-(2-i-propoxy-5-nitrobenzylidene) ruthenium(II) diiodide (CAS 1874264-99-9)
- Methyl 2-(3-(2-nitrophenyl)-1H-1,2,4-triazol-1-yl)acetate (CAS 1416338-89-0)
- 2-((5-(4-Chlorophenyl)-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)-N-phenylacetamide (CAS 443738-35-0)
- morpholine-2-carboxamide (CAS 135072-13-8)
- (S)-4-((1H-indol-3-yl)methyl)-2-methyl-4,5-dihydrooxazole (CAS 2195357-71-0)
- 2-methoxy-2-(4-methylphenyl)ethan-1-amine (CAS 1247043-24-8)
- 3-{[5-(Trifluoromethyl)-1,3,4-thiadiazol-2-yl]oxy}benzaldehyde (CAS 1065076-43-8)
- 4-(3-azidopropylamino)-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione (CAS 2357108-05-3)
- Semaglutide impurity 196 (CAS CATO-C4X-2226196)
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