2-Chloro-4-phenylnicotinaldehyde CAS 877054-52-9
| CAS No. | 877054-52-9 |
| Molecular Formula | C12H8ClNO |
| Molecular Weight | 217.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Chloro-4-phenylnicotinaldehyde.
2-Chloro-4-phenylnicotinaldehyde (CAS 877054-52-9), molecular formula C12H8ClNO and molecular weight 217.65 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-Chloro-4-phenylnicotinaldehyde (C12H8ClNO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-Chloro-4-phenylnicotinaldehyde meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H8ClNO |
| Molecular Weight | 217.65 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 8-Chloro-7-fluoro-2H-benzo[b][1,4]thiazin-3(4H)-one (CAS 101337-95-5)
- 6-Chloro-N-(2,2-dimethoxyethyl)pyrimidin-4(3H)-imine (CAS 1159822-73-7)
- 1-Chloro-10H-phenoxazine (CAS 116366-11-1)
- 6-Chloro-4-fluoro-2-hydrazinylbenzo[d]thiazole (CAS 1177300-26-3)
- (2-Chloro-3-(dimethoxymethyl)pyridin-4-yl)methanol (CAS 1186310-66-6)
- 5-Chloro-2-phenylisonicotinaldehyde (CAS 1227582-75-3)
- Methyl 3-(4-chloro-1h-pyrazol-1-yl)-2-(methylamino)propanoate (CAS 1250847-38-1)
- 3-(4-Chloro-1h-pyrazol-1-yl)-2-methyl-2-(methylamino)propanoic acid (CAS 1251244-35-5)
Recommended Standards
- 2-Chloro-10H-phenoxazine (CAS 56821-03-5)
- 2-Chloro-6-methoxy-4-((methoxymethoxy)methyl)pyridine (CAS 888729-53-1)
- 2-(4-Chlorophenyl)nicotinaldehyde (CAS 885950-19-6)
- 2-Chloro-9-methyl-9H-pyrimido[4,5-b]indole (CAS 26773-55-7)
- (S)-2,2-Difluoro-1-(3-fluorophenyl)ethan-1-ol (CAS 1821734-28-4)
- N1-Isopropyl-N1-methylethane-1,2-diamine dihydrochloride (CAS 1609403-04-4)
- N-(4-Bromophenyl)-3-methylbut-2-enamide (CAS 135631-89-9)
- n-(1-Cyclohexylethyl)-3-ethoxypropan-1-amine (CAS 1157569-16-8)
- Bismuth(III) gallate basic hydrate (CAS 312623-77-1)
- Lactaroviolin (CAS 85-33-6)
- Butyl[(2,3-dichlorophenyl)methyl]amine (CAS 774556-27-3)
- 5-(4-Methoxyphenyl)-1-(3-(trifluoromethyl)phenyl)-1H-tetrazole (CAS 339108-65-5)
- 5-[2-(cyclobutoxy)-4-fluoro-phenyl]-1,3,9-triazaspiro[5.5]undecan-2-one (CAS 2413107-81-8)
- Semaglutide Impurity 161 (x TFA Salt) (CAS CATO-C4X-2226161)
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