Crizotinib Impurity 3 CAS 877399-00-3
| CAS No. | 877399-00-3 |
| Molecular Formula | C13H10BrCl2FN2O |
| Molecular Weight | 380.04 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Crizotinib Impurity 3 (CAS 877399-00-3) is a certified pharmaceutical impurity reference standard with the molecular formula C13H10BrCl2FN2O and a molecular weight of 380.04 g/mol.
Crizotinib Impurity 3 (C13H10BrCl2FN2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine/bromine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Crizotinib Impurity 3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H10BrCl2FN2O |
| Molecular Weight | 380.04 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl/Br-containing |
| Nitrogen Atoms | 2 |
Related Crizotinib Standards
- Crizotinib impurity 36 (CAS CATO-C4X-102536)
- Crizotinib impurity 37 (CAS CATO-C4X-102537)
- Crizotinib impurity 38 (CAS CATO-C4X-102538)
- Crizotinib impurity 39 (CAS CATO-C4X-102539)
- Crizotinib Impurity 47 (CAS CATO-C4X-102547)
- Crizotinib Impurity 9 (CAS 1448326-33-7)
- Crizotinib impurity 14 (CAS CATO-C4X-102514)
- Crizotinib impurity 29 (CAS CATO-C4X-102529)
Recommended Standards
- 8-Bromo-7-(3-bromopropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione (CAS 93883-68-2)
- 8-Bromo-7-(2-bromopropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione (CAS 255730-94-0)
- [5-Bromo-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-yl]amine (CAS 756503-69-2)
- 6-Bromo-2-(4-bromophenyl)imidazo[1,2-a]pyridine-3-carbaldehyde (CAS 727652-13-3)
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- Moxifloxacin impurity 180 (CAS 151213-45-5)
- Tert-butyl ((S)-1-((S)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)carbamate (CAS 1416709-77-7)
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- Insulin Degludec Impurity 8 (CAS CATO-C4X-21578)
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