5-(4-Nitrophenyl)picolinic acid CAS 87789-78-4
| CAS No. | 87789-78-4 |
| Molecular Formula | C12H8N2O4 |
| Molecular Weight | 244.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-(4-Nitrophenyl)picolinic acid.
5-(4-Nitrophenyl)picolinic acid (CAS 87789-78-4) is a high-purity analytical reference standard with the molecular formula C12H8N2O4 and a molecular weight of 244.20 g/mol.
The molecular framework of 5-(4-Nitrophenyl)picolinic acid (C12H8N2O4) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H8N2O4 |
| Molecular Weight | 244.20 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Nitrogen Atoms | 2 |
Related Nitrophenyl Standards
- 2-(3-Nitrophenyl)isonicotinic acid (CAS 1261949-20-5)
- 2-(3-Nitrophenyl)nicotinic acid (CAS 937601-72-4)
- 4-Nitrophenyl picolinate (CAS 74104-89-5)
- 5-(3-Nitrophenyl)nicotinic Acid (CAS 898907-67-0)
- 6-(3-Nitrophenyl)nicotinic acid (CAS 887976-00-3)
- 6-(3-Nitrophenyl)picolinic Acid (CAS 80021-34-7)
- 6-(4-Nitrophenyl)picolinic acid (CAS 80021-26-7)
- N-(2-nitrophenyl)pyrazine-2-carboxamide (CAS 2604-91-3)
Recommended Standards
- 5-(4-Carboxyphenyl)pyrimidine-2-carboxylic acid (CAS 2137753-50-3)
- 5,6,7,8-Tetrabromo-2-(3-hydroxyquinolin-2-yl)-1H-cyclopenta[b]naphthalene-1,3(2H)-dione (CAS 62404-64-2)
- 5-Hydroxy-2-deoxyuridine (CAS 5168-36-5)
- 4-Oxobenzofuro[3,2-d]pyrimidine-3(4H)-acetic acid (CAS 257613-44-8)
- 4-Chloro-2-(2-fluorophenyl)pyridine (CAS 918530-84-4)
- 5-Chloro-2-naphthoic acid (CAS 56961-89-8)
- 5-(Chloromethyl)-3-(4-methoxyphenoxymethyl)-1,2,4-oxadiazole (CAS 923258-15-5)
- Linezolid Impurity 91 (CAS CATO-C4X-107391)
- Triphenylphosphine-3,3',3''-trisulfonic Acid Trisodium Salt (CAS 63995-70-0)
- 2-Amino-3-(2-methyl-3-(trifluoromethyl)phenyl)propanoic acid (CAS 1260004-91-8)
- 3-(1-hydroxyethyl)-5-[(4-methoxyphenyl)methyl]-1,4-dihydropyrrolo[3,4-c]pyrazol-6-one (CAS 2228971-14-8)
- 4-(Cyclohexyloxy)-3-iodophenol (CAS 1243473-01-9)
- 1-(4-Fluorophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carbohydrazide (CAS 618090-96-3)
- Gly-Neuroendocrine Regulatory Peptide-3 (human, mouse, rat) trifluoroacetate salt (CAS 1815618-19-9)
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