Tert-butyl (E)-3-(1-fluoro-2-hydroxyethylidene)piperidine-1-carboxylate CAS 878590-49-9
| CAS No. | 878590-49-9 |
| Molecular Formula | C12H20FNO3 |
| Molecular Weight | 245.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 245.29 g/mol gives Tert-butyl (E)-3-(1-fluoro-2-hydroxyethylidene)piperidine-1-carboxylate distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Tert-butyl (E)-3-(1-fluoro-2-hydroxyethylidene)piperidine-1-carboxylate (CAS 878590-49-9), molecular formula C12H20FNO3 and molecular weight 245.29 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Tert-butyl (E)-3-(1-fluoro-2-hydroxyethylidene)piperidine-1-carboxylate (C12H20FNO3) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Tert-butyl (E)-3-(1-fluoro-2-hydroxyethylidene)piperidine-1-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H20FNO3 |
| Molecular Weight | 245.29 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- Tert-butyl (4S,5R)-5-fluoro-1-oxa-7-azaspiro[3.5]Nonane-7-carboxylate (CAS 2216758-75-5)
- Tert-butyl 1-fluoro-5-methoxy-3-azabicyclo[3.1.1]Heptane-3-carboxylate (CAS 2413900-24-8)
- rel-tert-Butyl (3R,4S)-3-fluoro-4-(2-oxoethyl)piperidine-1-carboxylate (CAS 2839311-92-9)
- tert-Butyl 3-ethyl-3-fluoro-4-oxopiperidine-1-carboxylate (CAS 2660254-28-2)
- Cis-2-(4-chlorophenyl)-5-methyl-3-(pyrazin-2-yl)thiazolidin-4-one (CAS 89442-17-1)
- 4-[2-(Benzoyloxy)ethyl]-1,3-dihydro-2H-indol-2-one (CAS 139122-18-2)
- tert-butyl 1-fluoro-3-oxo-cyclobutanecarboxylate (CAS 2231676-34-7)
- Maxacalcitol Impurity 20 (CAS 192573-35-6)
- tert-Butyl 2,3-dihydro-1,4-benzoxazine-4-carboxylate (CAS 212180-23-9)
- 17892-25-0 3,5-Dibromosalicylamide 3,5-dibromo-2-hydroxybenzamide (CAS 17892-25-0)
- (S)-2-(Ethyl(1-methylpyrrolidin-3-yl)amino)acetic acid (CAS 1353998-31-8)
- 1-(aminomethyl)-3-ethoxycyclobutan-1-ol (CAS 1699420-62-6)
- (2S)-2-Amino-1-(3-(methoxymethyl)piperidin-1-yl)propan-1-one (CAS 1354024-32-0)
- D-Lys20-Tirzepatide (CAS CATO-CPTD788914)
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