2-Chloro-3-fluoro-4-iodoaniline CAS 880652-49-3
| CAS No. | 880652-49-3 |
| Molecular Formula | C6H4ClFIN |
| Molecular Weight | 271.46 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Chloro-3-fluoro-4-iodoaniline (CAS 880652-49-3) is a high-purity analytical reference standard with the molecular formula C6H4ClFIN and a molecular weight of 271.46 g/mol.
The molecular framework of 2-Chloro-3-fluoro-4-iodoaniline (C6H4ClFIN) is characterized by a nitrile group, fluorine/chlorine/iodine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-Chloro-3-fluoro-4-iodoaniline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H4ClFIN |
| Molecular Weight | 271.46 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl/I-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 2-Chloro-4-fluoro-6-iodoaniline (CAS 1005196-28-0)
- 4-Chloro-3-fluoro-2-iodoaniline (CAS 1018450-37-7)
- 4-Chloro-5-fluoro-2-iodoaniline (CAS 1094759-93-9)
- 4-Chloro-2-fluoro-5-iodoaniline (CAS 1350475-34-1)
- 3-Chloro-4-fluoro-2-iodoaniline (CAS 1383976-69-9)
- 2-Chloro-4-fluoro-3-iodoaniline (CAS 1392429-93-4)
- 2-Chloro-3-fluoro-5-iodo-4-methylpyridine (CAS 153035-01-9)
- 3-Chloro-5-fluoro-4-iodoaniline (CAS 1849390-96-0)
Recommended Standards
- 5-Chloro-2-fluoro-4-iodoaniline (CAS 1935087-03-8)
- 2-Chloro-4-fluoro-5-iodoaniline (CAS 2091569-03-6)
- Ethyl methyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate (CAS 19239-56-6)
- 2-Chloro-5-fluoro-4-iodo-3-methylpyridine (CAS 884494-50-2)
- 3-Iodo-4,5-dimethyl-1H-pyrazole (CAS 1533443-11-6)
- 2-((4-Chlorophenyl)(cyano)methyl)benzonitrile (CAS 127667-18-9)
- 1-((4-Bromothiophen-2-yl)methyl)-1H-pyrrole-3-carboxylic acid (CAS 1515396-01-6)
- 1-(4-Chlorophenyl)-2,2-difluoroethyl diethyl phosphate (CAS 2108663-79-0)
- Methyl (cyano(2,3-difluorophenyl)methyl)glycinate (CAS 1260667-51-3)
- 3-methyl-5-nitro-1H-indole (CAS 61861-88-9)
- Ethyl 2-(m-tolyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-3-carboxylate (CAS 2416673-84-0)
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- 1-Ethyl-1,2,3,6-tetrahydro-4-(methylthio)-1,3,5-triazine Hydroiodide (CAS 1189289-64-2)
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