Progesterone Impurity 36 CAS 88128-61-4
| CAS No. | 88128-61-4 |
| Molecular Formula | C23H34O4 |
| Molecular Weight | 374.51 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Progesterone Impurity 36.
Progesterone Impurity 36 (CAS 88128-61-4) is a certified pharmaceutical impurity reference standard with the molecular formula C23H34O4 and a molecular weight of 374.51 g/mol.
The molecular framework of Progesterone Impurity 36 (C23H34O4) is characterized by a flavonoid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H34O4 |
| Molecular Weight | 374.51 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
Related Progesterone Standards
- Progesterone Impurity 35 (CAS 88128-62-5)
- Progesterone Impurity 21 (CAS 19633-95-5)
- Progesterone Impurity 88 (CAS 6723-95-1)
- Progesterone Impurity 47 (CAS CATO-C4X-150247)
- Progesterone EP Impurity D (CAS 5035-09-6)
- Progesterone EP Impurity E (CAS 5062-62-4)
- Progesterone Impurity 82 (CAS 63088-24-4)
- Progesterone Impurity 92 (CAS CATO-C4X-150292)
Recommended Standards
- Busulfan Impurity 10 (CAS CATO-C4X-145510)
- Calcitroic Acid (CAS 71204-89-2)
- Pregnenolone 17α-Acetoxy (CAS 2381-45-5)
- Estradiol Impurity 33 (CAS CATO-C4X-163633)
- Buserelin EP Impurity B (CAS CATO-C4X-22122)
- Cefaclor Impurity 64 (CAS CATO-C4X-127064)
- Propofol EP Impurity B (CAS 74926-89-9)
- 2-Naphthalenol,3-bromo- 30478-88-7 CTK4G5271 (CAS 30478-88-7)
- Methyl 2-(4-methoxyphenyl)imidazo[1,2-a]pyridine-6-carboxylate (CAS 866050-80-8)
- (6-Methoxypyridin-3-yl)methanamine dHCl (CAS 169045-12-9)
- 5-Chloro-N-((dimethylamino)methylene)-1-(4-nitrobenzyl)-3-phenyl-1H-indole-2-carboxamide (CAS 400081-33-6)
- Methyl 3,5-dibromo-4-fluorophenylacetate (CAS 1806346-00-8)
- tert-Butyl 2-(furan-2-yl)piperidine-1-carboxylate (CAS 1355219-12-3)
- Semaglutide Impurity 166 (CAS 1395881-03-4)
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