(2E)-3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-N-(5-fluoro-2-methylphenyl)prop-2-enamide CAS 882081-67-6
| CAS No. | 882081-67-6 |
| Molecular Formula | C18H16FNO3 |
| Molecular Weight | 313.32 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures (2E)-3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-N-(5-fluoro-2-methylphenyl)prop-2-enamide under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
(2E)-3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-N-(5-fluoro-2-methylphenyl)prop-2-enamide (CAS 882081-67-6), molecular formula C18H16FNO3 and molecular weight 313.32 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (2E)-3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-N-(5-fluoro-2-methylphenyl)prop-2-enamide (C18H16FNO3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C18H16FNO3 |
| Molecular Weight | 313.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related E Standards
- (2E)-3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-N-(3-fluoro-4-methylphenyl)prop-2-enamide (CAS 882081-77-8)
- (2E)-3-(2,3-Dihydro-1,4-benzodioxin-6-yl)-N-[(4-fluorophenyl)methyl]prop-2-enamide (CAS 882081-92-7)
- 1-(2,3-Dihydro-1,4-benzodioxine-6-sulfonyl)pyrrolidine-2-carboxylic acid (CAS 1008191-83-0)
- 3-[(2,3-dihydro-1,4-benzodioxin-6-ylcarbonyl)amino]-4-methylbenzoic acid (CAS 923854-18-6)
- 5-(1,2-Dihydro-[1,1':4',1''-terphenyl]-2-yl)-3H-1,2,4-triazol-3-one (CAS 1000575-71-2)
- 2,3-Dihydro-2-spiro-4'-[8'-aminonaphthalen-1'(4'H)-one]perimidine (contains o-form) (CAS 851768-63-3)
- 3,6-Dihydro-2H,6'H-5,5'-bi[1,4]dithiino[2,3-c]pyrrole (CAS 675202-13-8)
- 2-Phenyl-2,3-dihydro-1H-indene (CAS 22253-11-8)
Recommended Standards
- (Z,Z,Z)-17-Bromo-3,6,9-Heptadecatriene (CAS 156559-07-8)
- (2Z)-4-(4-Ethoxyphenyl)-N-(4-fluorophenyl)-4-oxobut-2-enamide (CAS 331461-93-9)
- Ethyl 2-(ethylthio)-6,7-difluoro-4-hydroxyquinoline-3-carboxylate (CAS 154330-67-3)
- 3-((Tert-butoxycarbonyl)amino)-3-(3-fluoro-4-methoxyphenyl)propanoic acid (CAS 886506-21-4)
- Dimethyl 1-methyl-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate (CAS 18064-04-5)
- 4-Chloro-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(2,2,2-trifluoroethyl)-1H-indazol-3-amine (CAS 2189684-53-3)
- 1-(2,3-Dimethylphenyl)-1H-pyrrole (CAS 37560-42-2)
- 5-(Bromomethyl)naphthalen-2-ol (CAS 1261784-18-2)
- 5-Chloro-4-methylbenzimidazole (CAS 1360938-85-7)
- 5-(3,4-Dihydro-2H-pyrrol-5-yl)-2-isopropoxypyridine (CAS 1352487-45-6)
- (2R,3R,4R,5R)-2-(acetoxymethyl)-5-methoxytetrahydrofuran-3,4-diyl diacetate (CAS 37077-80-8)
- (R)-3-(7-bromo-1H-indol-3-yl)-2-((tert-butoxycarbonyl)amino)propanoic acid (CAS 1384101-99-8)
- N-(4-Ethynylphenyl)-3-(trifluoromethyl)benzamide (CAS 860788-59-6)
- Neuropeptide AF (human) (CAS 192387-38-5)
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