2-Chloro-5-(3-nitrophenyl)-1,3,4-thiadiazole CAS 88541-06-4

Purity 97%+In StockPharmaceutical Standards
CAS No.88541-06-4
Molecular FormulaC8H4ClN3O2S
Molecular Weight241.65 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

2-Chloro-5-(3-nitrophenyl)-1,3,4-thiadiazole CAS 88541-06-4 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 241.65 g/mol gives 2-Chloro-5-(3-nitrophenyl)-1,3,4-thiadiazole distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

2-Chloro-5-(3-nitrophenyl)-1,3,4-thiadiazole (CAS 88541-06-4), molecular formula C8H4ClN3O2S and molecular weight 241.65 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 2-Chloro-5-(3-nitrophenyl)-1,3,4-thiadiazole (C8H4ClN3O2S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 2-Chloro-5-(3-nitrophenyl)-1,3,4-thiadiazole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC8H4ClN3O2S
Molecular Weight241.65 g/mol
Purity97%+
StorageStore at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)8.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1982
Halogen ContentCl-containing
Nitrogen Atoms3
Sulfur Atoms1

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