2,4,6-Trifluoro-3-methoxybenzoic acid CAS 886499-94-1
| CAS No. | 886499-94-1 |
| Molecular Formula | C8H5F3O3 |
| Molecular Weight | 206.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2,4,6-Trifluoro-3-methoxybenzoic acid (CAS 886499-94-1), molecular formula C8H5F3O3 and molecular weight 206.12 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2,4,6-Trifluoro-3-methoxybenzoic acid (C8H5F3O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), 2,4,6-Trifluoro-3-methoxybenzoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5F3O3 |
| Molecular Weight | 206.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
Related Trifluoro Standards
- 2,2,3-Trifluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-ol (CAS 1008452-11-6)
- 2,3,3-TRifluoro-2-hydrobenzo[1,4]-dioxen-5-ol (CAS 1008452-12-7)
- 2,4,5-Trifluoro-3-Methoxybenzoic Acid (CAS 11281-65-5)
- 3,4,5-Trifluoro-α-hydroxybenzeneacetic acid (CAS 1214323-60-0)
- Methyl 2,3,5-trifluoro-4-hydroxybenzoate (CAS 1214387-26-4)
- 3,4,5-Trifluoro-N-methyl-2-nitroaniline (CAS 1346521-33-2)
- Methyl 2,4,5-trifluoro-3-hydroxybenzoate (CAS 137234-92-5)
- 2,2,2-trifluoro-N-(1-hydroxypyridin-4-ylidene)acetamide (CAS 1391054-01-5)
Recommended Standards
- 2,2-Difluoro-2-(4-fluorophenoxy)acetic acid (CAS 338792-64-6)
- 2-amino-6-(Trifluoromethyl)nicotinic acid (CAS 890302-02-0)
- 2-(Hydroxymethyl)-6-(trifluoromethyl)pyrimidine-4-carbaldehyde (CAS 944901-88-6)
- 2-Hydroxy-2-(2,3,6-trifluorophenyl)acetic acid (CAS 374633-23-5)
- 1-(5-Aminoindolin-1-yl)-2-methylpropan-1-one (CAS 1018508-06-9)
- 5-Amino-1-isopropyl-1H-pyrazol-3-ol (CAS 78317-68-7)
- 4-((3-(Benzyloxy)-4-methoxybenzylidene)amino)-3-(2-fluorophenyl)-1H-1,2,4-triazole-5(4H)-thione (CAS 677754-75-5)
- (5-(2-Amino-4-methylphenyl)furan-2-yl)methanol (CAS 875001-59-5)
- 2-(2-Amino-5-chlorophenoxy)ethan-1-ol (CAS 748806-08-8)
- 3-(4-methoxyphenoxy)propane-1-sulfonamide (CAS 919353-97-2)
- Thiophanate-methyl-d6 (O,O-dimethyl-d6) (CAS 1398065-77-4)
- 2-(2-((2-Fluorophenyl)amino)thiazol-4-yl)phenol hydrobromide (CAS 1211414-44-6)
- 4-(Methylthio)benzo[d]oxazole-2-carboxylic acid (CAS 1803745-59-6)
- Tirzepatide Impurity 16 (CAS CATO-C4X-324016)
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