2-Methyl-4-[4-(trifluoromethoxy)phenyl]-1,3-thiazole-5-carboxylic acid CAS 887267-81-4
| CAS No. | 887267-81-4 |
| Molecular Formula | C12H8F3NO3S |
| Molecular Weight | 303.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Methyl-4-[4-(trifluoromethoxy)phenyl]-1,3-thiazole-5-carboxylic acid.
CATO supplies 2-Methyl-4-[4-(trifluoromethoxy)phenyl]-1,3-thiazole-5-carboxylic acid (CAS 887267-81-4), a certified reference material (molecular formula C12H8F3NO3S, MW 303.26 g/mol) for analytical method development and quality control.
Structurally, 2-Methyl-4-[4-(trifluoromethoxy)phenyl]-1,3-thiazole-5-carboxylic acid (C12H8F3NO3S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 303.26 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H8F3NO3S |
| Molecular Weight | 303.26 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Methyl Standards
- 2-(2-(4-(Trifluoromethoxy)phenyl)thiazol-5-yl)acetic acid (CAS 1010918-95-2)
- {2-[4-(Trifluoromethoxy)phenyl]-1,3-thiazol-4-yl}acetic acid (CAS 1092330-87-4)
- 4-Methyl-2-(4-(trifluoromethoxy)phenyl)thiazole-5-carboxylic acid (CAS 187998-69-2)
- 1-((3-(Trifluoromethoxy)phenyl)amino)cyclohexane-1-carboxylic acid (CAS 1305770-58-4)
- 2-((1-(4-(Trifluoromethoxy)phenyl)-1H-pyrrol-2-yl)methylene)malononitrile (CAS 260788-89-4)
- 2-((1-(4-(Trifluoromethoxy)phenyl)-1H-pyrrol-3-yl)methylene)malononitrile (CAS 439094-26-5)
- 2-({[3-(trifluoromethoxy)phenyl]methyl}carbamoyl)cyclopropane-1-carboxylic acid (CAS 1024144-58-8)
- 2-{5-Oxo-4-[4-(trifluoromethoxy)phenyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid (CAS 860612-21-1)
Recommended Standards
- 2,2,2-trifluoroethyl N-(5-phenyl-1,3,4-thiadiazol-2-yl)carbamate (CAS 226983-84-2)
- 5-(((5-(Trifluoromethyl)pyridin-2-yl)thio)methyl)furan-2-carboxylic acid (CAS 238742-86-4)
- 2-(Benzenesulfonyl)-5-(trifluoromethyl)pyridin-3-ol (CAS 338956-57-3)
- Methyl (1r,4r)-4-(5-(difluoromethyl)-4-nitro-1H-pyrazol-1-yl)cyclohexane-1-carboxylate (CAS 2434852-20-5)
- (2-Chloro-3-fluoro-6-iodophenyl)methanol (CAS 1454851-49-0)
- 3-(Cyclohex-2-en-1-yloxy)-4-methoxybenzaldehyde (CAS 176756-92-6)
- 2-(Thiophen-3-yl)-1,3,2-dioxaborolane (CAS 718640-75-6)
- Methyl 2-methylmorpholine-2-carboxylate hydrochloride (CAS 1205750-77-1)
- 4-(2-(4-Methoxyphenyl)hydrazono)isochroman-1,3-dione (CAS 339021-24-8)
- 2-(2-Chlorophenyl)oxazole-4-carbaldehyde (CAS 885274-43-1)
- 2-(Difluoromethoxy)-5-nitrobenzonitrile (CAS 1403566-05-1)
- 2-(4-Amino-1h-pyrazol-1-yl)-N-cyclopropylpropanamide (CAS 1152505-76-4)
- 3,4-Dimethoxy-1,2,5-thiadiazole 1,1-dioxide (CAS 55904-83-1)
- Cholecystokinin Octapeptide (1-5) (desulfated) (CAS 121880-96-4)
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