3-(4-(Trifluoromethyl)phenyl)thiomorpholine CAS 887344-29-8
| CAS No. | 887344-29-8 |
| Molecular Formula | C11H12F3NS |
| Molecular Weight | 247.28 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 3-(4-(Trifluoromethyl)phenyl)thiomorpholine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
3-(4-(Trifluoromethyl)phenyl)thiomorpholine (CAS 887344-29-8) is a high-purity analytical reference standard with the molecular formula C11H12F3NS and a molecular weight of 247.28 g/mol.
The molecular framework of 3-(4-(Trifluoromethyl)phenyl)thiomorpholine (C11H12F3NS) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C11H12F3NS |
| Molecular Weight | 247.28 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Trifluoromethyl Standards
- 3-[3-(trifluoromethyl)phenyl]thiomorpholine (CAS 1342431-41-7)
- (2-(4-((Trifluoromethyl)thio)phenyl)cyclopropyl)methanamine (CAS 1468612-03-4)
- 5-(4-(Trifluoromethyl)phenoxy)pentan-1-amine (CAS 1274031-83-2)
- 2-(Ethyl(3-(trifluoromethyl)benzyl)amino)ethanol (CAS 1353983-43-3)
- 1-((4-(Trifluoromethyl)benzyl)oxy)butan-2-amine (CAS 1779134-91-6)
- 3-(4-(Trifluoromethyl)phenyl)thiazolidin-4-one (CAS 109052-21-3)
- 3-(Trifluoromethyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one (CAS 110579-29-8)
- (E)-2-(3-(trifluoromethyl)benzylidene)hydrazine-1-carbothioamide (CAS 264148-89-2)
Recommended Standards
- 3-(3-Methoxyphenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-amine (CAS 588719-28-2)
- 3-(4-Methoxyphenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-amine (CAS 3176-54-3)
- 3-(2-Methoxyphenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-amine (CAS 893643-31-7)
- 4-(1H-Tetrazol-5-yl-methyl)-4H-benzo[1,4]thiazin-3-one (CAS 874765-99-8)
- Oxazolo[5,4-c]pyridin-2(1H)-one (CAS 68523-29-5)
- (R)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-(3-hydroxybenzyl)propanoic acid (CAS 1260611-62-8)
- tert-Butyl 2-(2-hydroxyethyl)piperazine-1-carboxylate hydrochloride (CAS 2055840-85-0)
- Ethyl 3-amino-4-[(2-furylmethyl)amino]benzoate (CAS 1220035-61-9)
- 3-Methyl-3,6-diazabicyclo[3.1.1]heptane bis(trifluoroacetic acid) (CAS 1059700-17-2)
- 2-(4-(Cyclopent-3-ene-1-carbonyl)morpholin-2-yl)acetic acid (CAS 1519350-68-5)
- 2,3-Dimethoxyanthracene (CAS 51790-19-3)
- N1-cyclohexyl-N1-ethyl-2-(trifluoromethyl)benzene-1,4-diamine (CAS 1220016-64-7)
- (S)-6-(tert-butyl)-2,3-dihydro-1H-inden-1-amine (CAS 1213089-00-9)
- Semaglutide impurity 273 (CAS CATO-C4X-2226273)
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