5-(4-(Trifluoromethoxy)phenyl)nicotinaldehyde CAS 887973-59-3

Purity 97%+In StockPharmaceutical Standards
CAS No.887973-59-3
Molecular FormulaC13H8F3NO2
Molecular Weight267.20 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

5-(4-(Trifluoromethoxy)phenyl)nicotinaldehyde CAS 887973-59-3 chemical structure

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-(4-(Trifluoromethoxy)phenyl)nicotinaldehyde.

5-(4-(Trifluoromethoxy)phenyl)nicotinaldehyde (CAS 887973-59-3) is a high-purity analytical reference standard with the molecular formula C13H8F3NO2 and a molecular weight of 267.20 g/mol.

Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, 5-(4-(Trifluoromethoxy)phenyl)nicotinaldehyde is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 267.20 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC13H8F3NO2
Molecular Weight267.20 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in chloroform, dichloromethane, ethyl acetate, DMSO
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)9.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1987
Halogen ContentF-containing
Nitrogen Atoms1

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