Methyl 3-(2,6-difluorobenzamido)-5-(4-ethoxyphenyl)thiophene-2-carboxylate CAS 890817-95-5
| CAS No. | 890817-95-5 |
| Molecular Formula | C21H17F2NO4S |
| Molecular Weight | 417.43 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Methyl 3-(2,6-difluorobenzamido)-5-(4-ethoxyphenyl)thiophene-2-carboxylate (C21H17F2NO4S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies Methyl 3-(2,6-difluorobenzamido)-5-(4-ethoxyphenyl)thiophene-2-carboxylate (CAS 890817-95-5), a certified reference material (molecular formula C21H17F2NO4S, MW 417.43 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Methyl 3-(2,6-difluorobenzamido)-5-(4-ethoxyphenyl)thiophene-2-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H17F2NO4S |
| Molecular Weight | 417.43 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Methyl Standards
- Ethyl 1-(5-(2,6-difluorobenzamido)pyridin-2-yl)-3,5-dimethyl-1H-pyrazole-4-carboxylate (CAS 477710-47-7)
- Methyl 2-(4-(2,4-difluorobenzamido)phenoxy)benzoate (CAS 866020-24-8)
- N-(2-(2,6-difluorobenzamido)ethoxy)-2,6-difluorobenzamide (CAS 338413-81-3)
- Methyl 2-((5-((2,6-difluorobenzamido)methyl)-1,3,4-oxadiazol-2-yl)thio)acetate (CAS 921085-88-3)
- Methyl 2-(2,6-difluorobenzamido)benzoate (CAS 679784-58-8)
- 4-(2,6-Difluorobenzamido)-1H-pyrazole-3-carboxylic acid (CAS 825618-95-9)
- 6-Benzyl-2-(2,6-difluorobenzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide hydrochloride (CAS 1177977-21-7)
- 2-(2,6-Difluorobenzamido)-6-ethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide hydrochloride (CAS 1216587-45-9)
Recommended Standards
- 2-({[4-(dimethylamino)-6-(methylthio)-1,3,5-triazin-2-yl]amino}methylidene)-4,4,4-trifluoro-1-(2-thienyl)butane-1,3-dione (CAS 649578-93-8)
- Pitavastatin Impurity 111 (CAS CATO-C4X-1037111)
- 2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-5-fluoro-1,2,3,4-tetrahydroisoquinoline-8-carboxylic acid (CAS 2138004-27-8)
- Moxifloxacin Impurity 13 (CAS 1620445-13-7)
- 6-(2-Hydroxypropan-2-yl)picolinic acid (CAS 1799890-65-5)
- (((2R,3S,4R,5R)-5-(6-Amino-8-((4-bromo-2,3-dioxobutyl)thio)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)triphosphoric acid (CAS 115678-79-0)
- (5-((2,5-Dimethylphenyl)carbamoyl)-2-fluorophenyl)boronic acid (CAS 1449142-54-4)
- N-(2,2-dimethylthietan-3-yl)pent-4-ynamide (CAS 1856244-92-2)
- rel-(3R,4S)-4-(4-Fluorophenyl)tetrahydro-3-furanamine (CAS 1063733-97-0)
- 4-((3-(Trifluoromethyl)pyridin-2-yl)oxy)benzaldehyde (CAS 1086379-05-6)
- 5-(3-Nitrophenyl)-1-(o-tolyl)-1H-imidazole-2-thiol (CAS 1105189-33-0)
- 3-methyl-1H-indazole-7-carbonitrile (CAS 1554584-26-7)
- 2-((1H-Pyrrol-1-yl)methyl)benzoic acid (CAS 73217-14-8)
- Semaglutide impurity 63 (CAS CATO-C4X-222663)
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