6-Chloro-5-methylpyrazolo[1,5-a]pyrimidin-2-yl acetate CAS 89355-95-3
| CAS No. | 89355-95-3 |
| Molecular Formula | C9H8ClN3O2 |
| Molecular Weight | 225.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
6-Chloro-5-methylpyrazolo[1,5-a]pyrimidin-2-yl acetate (CAS 89355-95-3), molecular formula C9H8ClN3O2 and molecular weight 225.63 g/mol, is a CATO reference standard with documented purity and traceability.
6-Chloro-5-methylpyrazolo[1,5-a]pyrimidin-2-yl acetate (C9H8ClN3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 6-Chloro-5-methylpyrazolo[1,5-a]pyrimidin-2-yl acetate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H8ClN3O2 |
| Molecular Weight | 225.63 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- Ethyl 7-chloro-1H-pyrazolo[4,3-B]pyridine-6-carboxylate (CAS 100478-04-4)
- 5-(5-chloro-2-methoxyphenyl)-1,3,4-oxadiazol-2-amine (CAS 1016686-46-6)
- Ethyl 5-chloro-3H-imidazo[4,5-b]pyridine-2-carboxylate (CAS 1044772-75-9)
- Ethyl 2-chloro-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate (CAS 1060816-62-7)
- ethyl 6-chloro-1H-pyrazolo[3,4-b]pyridine-3-carboxylate (CAS 1083181-27-4)
- 5-Chloro-1,3-dimethyl-1H,2H,3H,4H-pyrido[2,3-d]pyrimidine-2,4-dione (CAS 112734-83-5)
- Methyl 4-chloro-2-cyano-5-methoxybenzoate (CAS 1138220-78-6)
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Recommended Standards
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- 2-(Methylthio)benzo[d]thiazole-5-carbonitrile (CAS 401567-16-6)
- 2-Chloro-N-cyclohexyl-N-(tetrahydro-1,1-dioxido-3-thienyl)acetamide (CAS 5553-25-3)
- 7-Amino-4-chloroindole (CAS 292636-12-5)
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- Semaglutide impurity 98 (CAS CATO-C4X-222698)
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