(E)-4-(Chloromethylene)-2-phenyloxazol-5(4H)-one CAS 89363-85-9
| CAS No. | 89363-85-9 |
| Molecular Formula | C10H6ClNO2 |
| Molecular Weight | 207.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies (E)-4-(Chloromethylene)-2-phenyloxazol-5(4H)-one (CAS 89363-85-9), a certified reference material (molecular formula C10H6ClNO2, MW 207.61 g/mol) for analytical method development and quality control.
The molecular framework of (E)-4-(Chloromethylene)-2-phenyloxazol-5(4H)-one (C10H6ClNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H6ClNO2 |
| Molecular Weight | 207.61 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related E Standards
- (Z)-4-(Chloromethylene)-2-phenyloxazol-5(4H)-one (CAS 89363-86-0)
- (chloromethylene)bis(trimethylsilane) 5926-35-2 Bis(trimethylsilyl)methyl chloride (CAS 5926-35-2)
- 4,4'-(Chloromethylene)bis(methoxybenzene) (CAS 7525-23-7)
- 4,4-(Chloromethylene)bis(chlorobenzene) (CAS 782-08-1)
- 2,2'-(Chloromethylene)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane) (CAS 2831415-88-2)
Recommended Standards
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- 1-Chloro-4-nitronaphthalene (CAS 605-61-8)
- (3-Chlorophenyl)(oxazol-2-yl)methanone (CAS 898759-75-6)
- Fmoc-L-Asparaginol (CAS 260450-76-8)
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- Z-Phe-Ala-diazomethylketone (CAS 71732-53-1)
- 2-(3-Amino-1h-pyrazol-1-yl)acetonitrile (CAS 1182932-54-2)
- Isopropyl 3-methyl-1H-indole-2-carboxylate (CAS 220679-14-1)
- Bilastine Impurity 21 (CAS 953071-73-3)
- 4-Amino-pyrazolo[1,5-a]pyridine-3-carboxylic acid ethyl ester (CAS 55899-23-5)
- Semaglutide impurity 236 (CAS CATO-C4X-2226236)
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