N-(4-Acetylphenyl)-4-ethyl-5-methylthiophene-3-carboxamide CAS 895933-27-4
| CAS No. | 895933-27-4 |
| Molecular Formula | C16H17NO2S |
| Molecular Weight | 287.38 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
N-(4-Acetylphenyl)-4-ethyl-5-methylthiophene-3-carboxamide (CAS 895933-27-4), molecular formula C16H17NO2S and molecular weight 287.38 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of N-(4-Acetylphenyl)-4-ethyl-5-methylthiophene-3-carboxamide (C16H17NO2S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H17NO2S |
| Molecular Weight | 287.38 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related N Standards
- N-(3-acetylphenyl)-4-ethyl-5-methylthiophene-3-carboxamide (CAS 895933-20-7)
- 5-(4-(4-Acetylphenyl)piperazin-1-yl)pyrrolidin-2-one (CAS 91703-13-8)
- 6-((3-Acetylphenyl)carbamoyl)cyclohex-3-ene-1-carboxylic acid (CAS 194801-16-6)
- 6-((4-Acetylphenyl)carbamoyl)cyclohex-3-ene-1-carboxylic acid (CAS 445260-21-9)
- N-(3-acetylphenyl)-2-(4-chlorophenyl)acetamide (CAS 72116-70-2)
- N-(3-Acetylphenyl)-2-chloro-2-phenylacetamide (CAS 568551-26-8)
- N-(4-acetylphenyl)-2-(4-chlorophenyl)acetamide (CAS 349425-56-5)
- 82753-84-2 N-(4-Acetylphenyl)-2-chloro-2-phenylacetamide MFCD00420501 (CAS 82753-84-2)
Recommended Standards
- n-(4-(((5-Amino-1,3,4-thiadiazol-2-yl)thio)methyl)thiazol-2-yl)acetamide (CAS 923127-74-6)
- N-(5-(Methylthio)-1,3,4-thiadiazol-2-yl)benzenesulfonamide (CAS 64140-83-6)
- N,N-Dibenzylethenesulfonamide (CAS 2525-74-8)
- N-(2,2-dimethoxyethyl)-2,4,6-trimethylbenzenesulfonamide (CAS 497061-22-0)
- 5-amino-1-phenyl-2,3-dihydro-1H-pyrazol-3-one (CAS 70373-98-7)
- (1-Ethyl-1H-pyrazol-3-yl)methanamine (CAS 956758-70-6)
- Bis(4-(dimethylamino)phenyl)(phenyl)methylium (CAS 14426-28-9)
- N-(4,6-Dichloropyrimidin-2-yl)acetamide (CAS 58910-75-1)
- Cyclohexyl 3-(phenylsulfonyl)-3-(4-(trifluoromethyl)phenyl)propanoate (CAS 2376300-24-0)
- 4-(4-Chlorobenzyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid (CAS 1146291-70-4)
- 2,3,4,6-Tetrafluorobenzeneboronic acid (CAS 511295-00-4)
- 4-Ethyl-1-methyl-3-(pyridin-4-yl)-1h-pyrazol-5-amine (CAS 1156895-03-2)
- 5-Amino-2-methylpyrimidine-4,6-diol (CAS 98797-08-1)
- Tirzepatide Impurity 10 (CAS CATO-C4X-324010)
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