3-Chloro-N-methyl-5-(trifluoromethyl)pyridin-2-amine CAS 89810-01-5
| CAS No. | 89810-01-5 |
| Molecular Formula | C7H6ClF3N2 |
| Molecular Weight | 210.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-Chloro-N-methyl-5-(trifluoromethyl)pyridin-2-amine (CAS 89810-01-5) is a high-purity analytical reference standard with the molecular formula C7H6ClF3N2 and a molecular weight of 210.58 g/mol.
The molecular framework of 3-Chloro-N-methyl-5-(trifluoromethyl)pyridin-2-amine (C7H6ClF3N2) is characterized by a nitrile group, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H6ClF3N2 |
| Molecular Weight | 210.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- (2-Chloro-6-(trifluoromethyl)pyridin-4-yl)methanamine (CAS 1060810-25-4)
- (5-Chloro-2-(trifluoromethyl)pyridin-4-yl)methanamine (CAS 1060810-32-3)
- 1-Chloro-3-(2,2,2-trifluoroethoxy)benzene (CAS 106854-78-8)
- (4-Chloro-6-(trifluoromethyl)pyridin-2-yl)methanamine (CAS 1196154-09-2)
- S 2-Chloro-1-(2,3,4-trifluoro-phenyl)-ethanol 1204756-51-3 A1-02931 (CAS 1204756-51-3)
- 6-Chloro-N-methyl-4-(trifluoromethyl)pyridin-2-amine (CAS 1208081-32-6)
- (6-Chloro-4-(trifluoromethyl)pyridin-3-yl)methanamine (CAS 1211534-84-7)
- 3-Chloro-4-methoxybenzotrifluoride (CAS 1214340-18-7)
Recommended Standards
- 3-Chloro-5-(trifluoromethyl)benzyl alcohol (CAS 886496-87-3)
- 4-(Trifluoromethoxy)benzyl Chloride (CAS 65796-00-1)
- 3-Chloro-5-(trifluoromethyl)anisole (CAS 886497-07-0)
- 4-Chloro-2-(trifluoromethyl)anisole (CAS 883497-29-8)
- D-Lyxose-1-C-d (CAS 288846-88-8)
- Dicyclohexyl(2,4,6-triisopropylphenyl)phosphine (CAS 303111-96-8)
- 2-chloro-3-methylquinoline-6-sulfonyl chloride (CAS 1181699-76-2)
- Nickel antimonide (CAS 12503-49-0)
- 4-Formyl-1-methylcyclohexanecarbonitrile (CAS 2169923-23-1)
- 4-[3-(pyrrolidin-1-yl)propyl]piperidine (CAS 933746-67-9)
- 1236256-93-1 2-Amino-N-(3-methoxypropyl)-3-methylbutanamide hydrochloride 2811AD C9H21ClN2O2 (CAS 1236256-93-1)
- 2-Chloro-1-(1,3,5-trimethyl-1h-pyrazol-4-yl)ethan-1-one (CAS 90002-88-3)
- 2-Ethynyl-5-fluorophenol (CAS 1882503-46-9)
- Semaglutide impurity 204 (CAS CATO-C4X-2226204)
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