Thiamine Impurity 26 CAS 89875-98-9
| CAS No. | 89875-98-9 |
| Molecular Formula | C6H10N4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Thiamine Impurity 26 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Thiamine Impurity 26 (CAS 89875-98-9), a pharmacopoeial impurity reference standard (molecular formula C6H10N4HCl, MW 174.63 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Thiamine Impurity 26 (C6H10N4HCl) is characterized by a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C6H10N4 HCl |
| Molecular Weight | 174.63 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Thiamine Standards
- Thiamine Impurity 30 (CAS 100502-51-0)
- Thiamine Nitrate EP Impurity G (CAS 1037-29-2)
- Thiamine Impurity 11 (CAS 105070-51-7)
- Thiamine /Vitamin B1 Impurity 50 (CAS 10553-88-5)
- Thiamine /Vitamin B1 Impurity 54 Ammonium Salt (CAS 10553-88-5 (free form))
- Thiamine EP Impurity F (CAS 10593-44-9)
- Thiamine disulfide (dinitrate) (CAS 109125-52-2)
- Thiamine Impurity 54 (CAS 1124-01-2)
Recommended Standards
- Rasagiline impurity 58 (CAS CATO-C4X-191358)
- Venetoclax Impurity 86 (CAS 35188-27-3)
- Finasteride Impurity 60 HCl (CAS CATO-C4X-164560)
- (1R,2S)-2-(2,4-dimethylbenzoyl)cyclohexane-1-carboxylic acid (CAS 85603-44-7)
- 2-((2-Acetamidophenyl)thio)acetamide (CAS 91843-03-7)
- Linuron-d6 (CAS 1219804-76-8)
- 2-(Chloromethyl)quinolin-4(1h)-one (CAS 946712-03-4)
- 2-(propan-2-yl)cyclobutan-1-one (CAS 27608-63-5)
- Ticagrelor Impurity 26 (CAS CATO-C4X-109326)
- Semaglutide impurity 236 (CAS CATO-C4X-2226236)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com