(3-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(3,4-difluorophenyl)methanone CAS 898762-37-3
| CAS No. | 898762-37-3 |
| Molecular Formula | C21H21F2NO3 |
| Molecular Weight | 373.39 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of (3-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(3,4-difluorophenyl)methanone is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
(3-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(3,4-difluorophenyl)methanone (CAS 898762-37-3) is a high-purity analytical reference standard with the molecular formula C21H21F2NO3 and a molecular weight of 373.39 g/mol.
The molecular framework of (3-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(3,4-difluorophenyl)methanone (C21H21F2NO3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H21F2NO3 |
| Molecular Weight | 373.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Dioxa Standards
- (2-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(2,4-difluorophenyl)methanone (CAS 898756-63-3)
- (2-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(3,4-difluorophenyl)methanone (CAS 898756-66-6)
- (2-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(3,5-difluorophenyl)methanone (CAS 898781-05-0)
- (3-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(2,4-difluorophenyl)methanone (CAS 898762-34-0)
- (3-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(3,5-difluorophenyl)methanone (CAS 898762-40-8)
- (4-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(2,4-difluorophenyl)methanone (CAS 898758-43-5)
- (4-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(3,4-difluorophenyl)methanone (CAS 898758-46-8)
- (4-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(3,5-difluorophenyl)methanone (CAS 898758-49-1)
Recommended Standards
- 2-Phenyl-N-(2-(3-(trifluoromethyl)phenoxy)ethyl)ethane-1-sulfonamide (CAS 1105204-44-1)
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- Ketotifen Impurity 29 (CAS CATO-C4X-204629)
- 2,4-Difluoro-N-(4-(((4-fluorophenyl)thio)methyl)phenyl)benzamide (CAS 338398-76-8)
- Fmoc-D-IsoGln-Trt (CAS 1228675-45-3)
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