1-(4-Chloro-2-fluorophenyl)-3-(2-methoxyphenyl)propan-1-one CAS 898770-45-1
| CAS No. | 898770-45-1 |
| Molecular Formula | C16H14ClFO2 |
| Molecular Weight | 292.73 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, a polycyclic aromatic system, 1-(4-Chloro-2-fluorophenyl)-3-(2-methoxyphenyl)propan-1-one is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 292.73 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
1-(4-Chloro-2-fluorophenyl)-3-(2-methoxyphenyl)propan-1-one (CAS 898770-45-1), molecular formula C16H14ClFO2 and molecular weight 292.73 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-(4-Chloro-2-fluorophenyl)-3-(2-methoxyphenyl)propan-1-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H14ClFO2 |
| Molecular Weight | 292.73 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
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Recommended Standards
- 1-(3-Chloro-5-fluorophenyl)-3-(2-methoxyphenyl)propan-1-one (CAS 898770-42-8)
- 1-(4-Chloro-2-fluorophenyl)-3-(4-methoxyphenyl)propan-1-one (CAS 898776-19-7)
- 1-(3-Chloro-4-fluorophenyl)-3-(4-methoxyphenyl)propan-1-one (CAS 898775-96-7)
- 1-(4-Chloro-3-fluorophenyl)-3-(2-methoxyphenyl)propan-1-one (CAS 898770-15-5)
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