1-(2,6-Dichlorophenyl)-3-(3,4-difluorophenyl)propan-1-one CAS 898777-52-1
| CAS No. | 898777-52-1 |
| Molecular Formula | C15H10Cl2F2O |
| Molecular Weight | 315.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(2,6-Dichlorophenyl)-3-(3,4-difluorophenyl)propan-1-one.
1-(2,6-Dichlorophenyl)-3-(3,4-difluorophenyl)propan-1-one (CAS 898777-52-1), molecular formula C15H10Cl2F2O and molecular weight 315.14 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1-(2,6-Dichlorophenyl)-3-(3,4-difluorophenyl)propan-1-one (C15H10Cl2F2O) is characterized by a hydroxyl group, an ether linkage, fluorine/chlorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H10Cl2F2O |
| Molecular Weight | 315.14 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
Related Dichlorophenyl Standards
- 1-(2,6-Dichlorophenyl)-3-(3,5-difluorophenyl)propan-1-one (CAS 898777-54-3)
- Methyl 2-(2-(3,5-dichlorophenyl)-5-methyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl)acetate (CAS 477711-21-0)
- 3-(2,4-Dichlorophenyl)-[1,2,4]triazolo[4,3-c]quinazoline (CAS 129177-17-9)
- 3-(3,4-Dichlorophenyl)-[1,2,4]triazolo[4,3-c]quinazoline (CAS 339025-82-0)
- Methyl 1-(2,4-dichlorophenyl)-4-hydroxy-6-oxo-1,6-dihydropyridazine-3-carboxylate (CAS 121582-57-8)
- 4-((5-(2,4-Dichlorophenyl)-1,3,4-oxadiazol-2-yl)thio)but-2-yn-1-ol (CAS 727386-58-5)
- 2-(2,4-Dichlorophenyl)-2,3-dihydro-1H-perimidine (CAS 64369-14-8)
- 2-(3,4-Dichlorophenyl)-3-thioxohexahydroimidazo[1,5-a]pyridin-1(5H)-one (CAS 60726-01-4)
Recommended Standards
- 6'-Bromo-7'-fluoro-1'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'(2'H)-dione (CAS 1849593-02-7)
- 2-Bromo-4-(4-methoxy-3-nitrophenyl)thiazole (CAS 1387562-68-6)
- 1-(3-Chloro-4-fluorophenyl)-3-(3-chloro-5-fluorophenyl)propan-1-one (CAS 898750-88-4)
- tert-Butyl 4-bromo-6-fluoro-1H-indazole-1-carboxylate (CAS 1333319-71-3)
- 1-Propanaminium, 3-chloro-2-hydroxy-N,N,N-trimethyl-, chloride , reaction products with polyethylenimine (CAS 68611-36-9)
- Dansyl-L-leucine cyclohexylammonium salt (CAS 42954-58-5)
- (6-Chloro-4-methylpyridin-3-yl)methanamine hydrochloride (CAS 1257535-38-8)
- (2S)-2-(((1S)-1-carboxy-5-(6-(3-(3-((2-((5-(2-carboxyethyl)-2-hydroxyphenyl)methyl-(carboxymethyl)amino)ethyl-(carboxymethyl)amino)methyl)-4-hydroxyphenyl)propanoylamino)hexanoylamino)pentyl)carbamoylamino)pentanedioic acid (CAS 1366302-52-4)
- 2-(Pyridine-3-amido)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid (CAS 314032-09-2)
- Imidazo[1,2-a]pyridin-5-ol (CAS 887576-32-1)
- Ethyl 7-nitroheptanoate (CAS 76455-55-5)
- (E)-Ethyl 4,4-diphenylbut-2-enoate (CAS 97634-46-3)
- (2S,5S)-1-(4-(tert-Butyl)phenyl)-2,5-bis(4-nitrophenyl)pyrrolidine (CAS 1258232-92-6)
- Semaglutide Impurity 143 (CAS CATO-C4X-2226143)
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