5-Methyl-2-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxylic acid CAS 900019-77-4
| CAS No. | 900019-77-4 |
| Molecular Formula | C10H7F3N2O2 |
| Molecular Weight | 244.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 5-Methyl-2-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxylic acid (CAS 900019-77-4), a certified reference material (molecular formula C10H7F3N2O2, MW 244.17 g/mol) for analytical method development and quality control.
The molecular framework of 5-Methyl-2-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxylic acid (C10H7F3N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H7F3N2O2 |
| Molecular Weight | 244.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Methyl Standards
- 3-Methyl-5-(trifluoromethyl)-1-benzofuran-2-carboxylic acid (CAS 1019115-65-1)
- 5-(3-(Trifluoromethyl)phenyl)imidazolidine-2,4-dione (CAS 1048367-95-8)
- 6-(Trifluoromethyl)imidazo[1,2-a]pyridine-2-carbohydrazide (CAS 1048912-65-7)
- 1-methyl-2-(trifluoromethyl)-1H-1,3-benzodiazole-5-carboxylic acid (CAS 1094264-29-5)
- Methyl 2-(trifluoromethyl)imidazo[1,2-a]pyridine-8-carboxylate (CAS 1116691-30-5)
- Methyl 5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-3-carboxylate (CAS 1190320-28-5)
- Methyl 5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate (CAS 1190320-31-0)
- Methyl 7-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate (CAS 1206972-64-6)
Recommended Standards
- 5-Cyano-3,4-dimethyl-6-(trifluoromethyl)picolinic acid (CAS 2581232-49-5)
- 6-methoxy-2-(trifluoromethyl)-1,4-dihydroquinazolin-4-one (CAS 301233-15-8)
- 4,6-Diamino-2-(trifluoromethyl)-2H,3H-furo[2,3-b]pyridine-5-carbonitrile (CAS 672951-58-5)
- 6-Methoxy-4-(trifluoromethyl)quinazolin-2(1H)-one (CAS 214288-03-6)
- Thulium chloride hydrate, 99.99% (CAS 19423-86-0)
- 1-(4-Ethoxyphenyl)-2,5-dimethyl-1H-pyrrole-3-carbaldehyde (CAS 347331-41-3)
- 2'-Fluoro-3'-methoxy-[1,1'-biphenyl]-2-carboxylic acid (CAS 1261932-56-2)
- 2-Bromoquinoline-8-carboxylic acid (CAS 1426144-88-8)
- 1-(5-Chloro-2-methylphenyl)-4,4-dimethyl-1,4-dihydropyrimidine-2-thiol (CAS 1142212-27-8)
- N-Benzyl-4-bromo-5-fluoro-2-nitroaniline (CAS 1330750-40-7)
- Ceftazidime impurity 113 (CAS CATO-C4X-1212113)
- 2-(2-Bromo-6-ethoxy-4-formylphenoxy)-N-(naphthalen-1-yl)acetamide (CAS 832674-12-1)
- 4-fluoro-5-((7-fluorobenzo[d][1,3]dioxol-4-yl)methyl)benzo[d][1,3]dioxole (CAS CATO-C3D-263190)
- Semaglutide impurity 237 (CAS CATO-C4X-2226237)
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