1-Bromo-5-chloro-2-methoxy-4-methylbenzene CAS 90004-78-7
| CAS No. | 90004-78-7 |
| Molecular Formula | C8H8BrClO |
| Molecular Weight | 235.51 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-Bromo-5-chloro-2-methoxy-4-methylbenzene (CAS 90004-78-7), molecular formula C8H8BrClO and molecular weight 235.51 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a hydroxyl group, an ether linkage, chlorine/bromine substitution, an aromatic ring system, 1-Bromo-5-chloro-2-methoxy-4-methylbenzene is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 235.51 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H8BrClO |
| Molecular Weight | 235.51 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | Cl/Br-containing |
Related Bromo Standards
- 1-(4-Bromo-2-chlorophenyl)ethan-1-ol (CAS 1002309-96-7)
- 1-Bromo-3-chloro-2-ethoxy-benzene (CAS 1010390-50-7)
- 5-Bromo-4-chloro-2-isopropylpyrimidine (CAS 1044767-89-6)
- 5-Bromo-4-chloro-6-isopropylpyrimidine (CAS 1044768-52-6)
- 2-Bromo-1-chloro-4-methoxymethyl-benzene (CAS 1079402-21-3)
- (5-Bromo-2-chlorobenzyl)hydrazine (CAS 1096824-50-8)
- 1-Bromo-4-(chloromethyl)-2-methoxybenzene (CAS 113081-49-5)
- 4-Bromo-3-chloro-2-methylanisole (CAS 1155264-58-6)
Recommended Standards
- 1-bromo-4-chloro-2-methoxy-5-methylbenzene (CAS 83803-57-0)
- 2-(2-Bromo-4-chlorophenyl)ethan-1-ol (CAS 52864-57-0)
- 1-Bromo-4-(2-chloroethoxy)benzene (CAS 55162-34-0)
- 2-(2-Bromo-5-chlorophenyl)ethan-1-ol (CAS 947614-94-0)
- 5,6-Dimethyl-N-(pyridin-2-ylmethyl)-1,3-benzothiazol-2-amine (CAS 1105191-66-9)
- 5-(3-Chloro-2-methylphenyl)-2-hydroxypyrimidine (CAS 1111109-06-8)
- 1-(6-Chloropyrimidin-4-yl)piperidine-4-carbonitrile (CAS 945896-87-7)
- 3-(4-Bromophenyl)isothiazolidine 1,1-dioxide (CAS 2138340-48-2)
- 4-((4'-Chloro-[1,1'-biphenyl])-4-sulfonamido)benzoic acid (CAS 885269-32-9)
- 5-Amino-4'-chloro-3'-cyano-[1,1'-biphenyl]-3-carboxylic acid (CAS 1261948-13-3)
- Tri(furan-2-yl)germane (CAS 96721-50-5)
- Phosphatidylethanolamines, soya (CAS 97281-51-1)
- 3-(Methanesulfonylmethyl)benzene-1-sulfonyl chloride (CAS 1248225-70-8)
- Semaglutide（sodium salt） (CAS CATO-C4X-222619)
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