Methoxamine Impurity 5 CAS 90253-98-8
| CAS No. | 90253-98-8 |
| Molecular Formula | C11H15NO3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Methoxamine Impurity 5.
Methoxamine Impurity 5 (CAS 90253-98-8) is a certified pharmaceutical impurity reference standard with the molecular formula C11H15NO3HCl and a molecular weight of 245.70 g/mol.
Structurally, Methoxamine Impurity 5 (C11H15NO3HCl) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 245.70 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Methoxamine Impurity 5 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H15NO3 HCl |
| Molecular Weight | 245.70 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Methoxamine Standards
- Methoxamine Impurity 23 (CAS 100840-93-5)
- Methoxamine Impurity 2 (CAS 103565-48-6)
- Methoxamine Impurity 10 (CAS 1201-38-3)
- Methoxamine Impurity 16 (CAS 121347-31-7)
- Methoxamine Impurity 6 (CAS 1835-04-7)
- Methoxamine Impurity 7 (CAS 29128-53-8)
- Methoxamine Impurity 9 (CAS 49710-99-8)
- Methoxamine Impurity 11 (CAS 54419-64-6)
Recommended Standards
- Osimertinib Impurity 69 (CAS CATO-C4X-204569)
- Sulpiride Impurity 12 (CAS CATO-C4X-187612)
- Regadenoson Impurity 27 (CAS 89365-25-3)
- 4-(3-(3,4-Dimethoxyphenyl)-1,2,4-oxadiazol-5-yl)-1-(3,5-dimethylphenyl)pyrrolidin-2-one (CAS 941955-18-6)
- N1-(2-Methoxybenzyl)-N2-(thiophen-3-ylmethyl)oxalamide (CAS 1060226-32-5)
- 4,5-Dichloro-1,6-dimethyl-1H-indole-2-carboxylic acid (CAS 2244454-05-3)
- (S)-tert-Butyl 2-((2-aminoacetamido)methyl)pyrrolidine-1-carboxylate (CAS 1354008-96-0)
- 2-(3-Fluorobenzamido)oxazole-4-carboxylic acid (CAS 1204298-09-8)
- 5-Chloro-2-fluoro-4-isopropoxyphenylboronic acid (CAS 2121511-67-7)
- Palmitoyl Tripeptide -5 · 2 TFA (CAS 623172-56-5)
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