Pentazocine Impurity N1 CAS 90278-52-7
| CAS No. | 90278-52-7 |
| Molecular Formula | C10H10O4 |
| Molecular Weight | 194.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Pentazocine Impurity N1 (CAS 90278-52-7), a pharmacopoeial impurity reference standard (molecular formula C10H10O4, MW 194.18 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Pentazocine Impurity N1 (C10H10O4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H10O4 |
| Molecular Weight | 194.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
Related Pentazocine Standards
- Pentazocine Impurity 6 (CAS 16808-63-2)
- Pentazocine Impurity 3 (CAS CATO-C4X-31643)
- Pentazocine impurity 1 (CAS 865-58-7)
- Pentazocine Impurity 4 (CAS CATO-C4X-31644)
- Pentazocine Impurity 5 (CAS 18175-34-3)
- Pentazocine Impurity 7 (CAS CATO-C4X-31647)
- (-)-cis-Pentazocine (CAS 7488-49-5)
- (+)-Pentazocine (CAS 7361-76-4)
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