2-(3-Bromo-4-methylphenyl)-1,3-thiazole CAS 903522-18-9
| CAS No. | 903522-18-9 |
| Molecular Formula | C10H8BrNS |
| Molecular Weight | 254.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-(3-Bromo-4-methylphenyl)-1,3-thiazole (CAS 903522-18-9) is a high-purity analytical reference standard with the molecular formula C10H8BrNS and a molecular weight of 254.15 g/mol.
The molecular framework of 2-(3-Bromo-4-methylphenyl)-1,3-thiazole (C10H8BrNS) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), 2-(3-Bromo-4-methylphenyl)-1,3-thiazole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H8BrNS |
| Molecular Weight | 254.15 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
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Recommended Standards
- 2-((6-Fluorospiro[3.3]heptan-2-yl)methyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2715119-86-9)
- 2-(4-Bromophenyl)-4-methyl-1,3-thiazole (CAS 850852-62-9)
- 2-(3-Bromophenyl)thiophen-3-amine (CAS 1889773-47-0)
- 2-(Bromomethyl)-4-phenylthiazole (CAS 78502-79-1)
- 2-(2-Chlorophenoxy)butanoyl chloride (CAS 344410-82-8)
- 5-Chloro-4-(((3-chlorophenyl)thio)methyl)-1-methyl-3-phenyl-1H-pyrazole (CAS 318234-08-1)
- 2'-Sulfamoyl-[1,1'-biphenyl]-3-carboxylic acid (CAS 1215206-45-3)
- 1-(2-(Allyloxy)-6-hydroxyphenyl)ethan-1-one (CAS 23226-84-8)
- Methyl 2,4-diaminobutanoate (CAS 37529-96-7)
- tert-Butyl 4-(4-bromo-2-chlorophenyl)piperazine-1-carboxylate (CAS 1429891-40-6)
- 3-Bromothiophene-2-boronic acid (CAS 162607-26-3)
- tert-Butyl (3-acetamido-5-formylbenzyl)carbamate (CAS 1393565-76-8)
- 4-(tert-Butoxy)-3-cyclopropoxy-2-iodopyridine (CAS 1243346-78-2)
- Insulin Pork(≥27 USP units/mg) (CAS 12584-58-6)
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