Bicalutamide EP Impurity A CAS 90357-05-4
| CAS No. | 90357-05-4 |
| Molecular Formula | C18H15F3N2O4S |
| Molecular Weight | 412.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 412.38 g/mol gives Bicalutamide EP Impurity A distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Bicalutamide EP Impurity A (CAS 90357-05-4, C18H15F3N2O4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution, Bicalutamide EP Impurity A is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 412.38 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H15F3N2O4S |
| Molecular Weight | 412.38 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Bicalutamide Standards
- Bicalutamide USP Related Compound A (CAS 945419-64-7)
- Bicalutamide EP Impurity E (CAS CATO-C4X-101325)
- Bicalutamide EP Impurity F (CAS CATO-C4X-101326)
- Bicalutamide Impurity 31 (CAS CATO-C4X-101331)
- Bicalutamide EP Impurity C (CAS 906008-94-4)
- Bicalutamide EP Impurity E (CAS CATO-C4X-10136)
- Bicalutamide EP Impurity F (CAS CATO-C4X-10137)
- Bicalutamide Impurity 28 (CAS CATO-C4X-101328)
Recommended Standards
- N-[(5Z)-5-{[(3,5-dimethoxyphenyl)amino]methylidene}-6-oxo-4H,5H,6H-cyclopenta[b]thiophen-4-yl]-2,2,2-trifluoroacetamide (CAS 865659-11-6)
- (2S,3R,4S,5R,6R)-6-(acetoxymethyl)-5-hydroxy-2-(4-methoxyphenoxy)tetrahydro-2H-pyran-3,4-diyl diacetate (CAS 1004771-43-0)
- 5-Methyl-4-((phenylsulfonyl)methyl)-1-(4-(trifluoromethoxy)phenyl)-1,3-dihydro-2H-imidazol-2-one (CAS 439095-99-5)
- Dimethyl (E)-2-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(benzo[d][1,3]dioxol-5-ylmethylene)succinate (CAS 103001-05-4)
- Mizolastine Impurity 7 (CAS CATO-C4X-20067)
- Pranoprofen Impurity 43 (CAS CATO-C4X-181143)
- Sitagliptin Impurity 150 (CAS 945261-47-2)
- 2-(2-Chloro-6-fluoropyridin-4-yl)ethan-1-amine (CAS 1393558-81-0)
- 5-Methyl-2H-1,2,6-thiadiazine-3-carboxylic acid 1,1-dioxide (CAS 924869-06-7)
- Ald-Ph-amido-PEG3-C2-Pfp ester (CAS 2101206-21-5)
- N-((1-(2-Aminoethyl)pyrrolidin-2-yl)methyl)-N-benzylethanamine (CAS 1353963-22-0)
- 6-Ethynyl-2,3-dihydro-1H-inden-1-amine (CAS 1417713-60-0)
- 2-(4-Chlorophenyl)-2-(methylamino)ethan-1-ol (CAS 1184060-74-9)
- D-Lys16-Tirzepatide (CAS CATO-CPTD788918)
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