1-(4-Acetylpiperazin-1-yl)-2,2,2-trifluoroethan-1-one CAS 90402-52-1
| CAS No. | 90402-52-1 |
| Molecular Formula | C8H11F3N2O2 |
| Molecular Weight | 224.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1-(4-Acetylpiperazin-1-yl)-2,2,2-trifluoroethan-1-one is closely related to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 1-(4-Acetylpiperazin-1-yl)-2,2,2-trifluoroethan-1-one (CAS 90402-52-1), a certified reference material (molecular formula C8H11F3N2O2, MW 224.18 g/mol) for analytical method development and quality control.
Structurally, 1-(4-Acetylpiperazin-1-yl)-2,2,2-trifluoroethan-1-one (C8H11F3N2O2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 3.0, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 224.18 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-(4-Acetylpiperazin-1-yl)-2,2,2-trifluoroethan-1-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H11F3N2O2 |
| Molecular Weight | 224.18 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Acetylpiperazin Standards
- 5-(4-Acetylpiperazin-1-yl)-1,2,4-triazin-3(4H)-one (CAS 879639-17-5)
- (S)-1-(4-Acetylpiperazin-1-yl)-2-amino-3-methylbutan-1-one (CAS 1176601-69-6)
- 4-(4-Acetylpiperazin-1-yl)-4-oxobutanoic acid (CAS 389056-48-8)
- Methyl 3-(4-acetylpiperazin-1-yl)-2-methylpropanoate (CAS 1154916-98-9)
- Methyl 3-(4-acetylpiperazin-1-yl)butanoate (CAS 1154981-48-2)
- 3-(4-Acetylpiperazin-1-yl)benzonitrile (CAS 1500989-31-0)
- 4-(4-Acetylpiperazin-1-yl)benzonitrile (CAS 186650-90-8)
- 1-(4-Acetylpiperazin-1-yl)-2-chloropropan-1-one (CAS 1016699-47-0)
Recommended Standards
- (E)-3-(Dimethylamino)-2-(2,2,2-trifluoro-1-hydrazino-1-hydroxyethyl)-2-propenenitrile (CAS 400086-95-5)
- 1-(4-Amino-1,2,5-oxadiazol-3-yl)-5-methyl-1H-1,2,3-triazole-4-carbohydrazide (CAS 324017-24-5)
- (4-((trimethylsilyl)ethynyl)phenyl)boronic acid (CAS 630127-51-4)
- 1-(Trifluoromethyl)naphthalene-2-carboxaldehyde (CAS 364064-69-7)
- tert-Butyl 2'-methyl-3',4'-dihydro-2'H-spiro[piperidine-4,1'-pyrrolo[1,2-a]pyrazine]-1-carboxylate (CAS 1392466-04-4)
- (3-((Benzyloxy)carbonyl)phenyl)boronic acid (CAS 380430-52-4)
- N'-(6-Chloropyridin-2-yl)-2,5-bis(2,2,2-trifluoroethoxy)benzohydrazide (CAS 338785-31-2)
- N1-cyclobutyl-N3,N3,2,2-tetramethylpropane-1,3-diamine (CAS 1249891-07-3)
- 2-(Hex-3-en-3-yl)benzo[d][1,3,2]dioxaborole (CAS 107648-56-6)
- 2,7-Dibromo-9,9-dipropylfluorene (CAS 157771-56-7)
- 3-Cyclohexyl-1-methyl-1H-pyrazole-4-carboxylic acid (CAS 1157394-06-3)
- 2-(Benzylamino)-N-(4-(sec-butyl)phenyl)-2-thioxoacetamide (CAS 329079-12-1)
- (2-Methyl-1,3-dioxoisoindolin-4-yl)carbamic Acid Benzyl Ester (CAS 1787992-87-3)
- Adrenal Peptide E, bovine (CAS 78355-50-7)
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