5-(2,2,2-Trifluoroethyl)isoindoline hydrochloride CAS 905274-65-9
| CAS No. | 905274-65-9 |
| Molecular Formula | C10H10F3N |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-(2,2,2-Trifluoroethyl)isoindoline hydrochloride (C10H10F3NHCl) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
5-(2,2,2-Trifluoroethyl)isoindoline hydrochloride (CAS 905274-65-9), molecular formula C10H10F3NHCl and molecular weight 237.65 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H10F3N HCl |
| Molecular Weight | 237.65 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Trifluoroethyl Standards
- 2,2,2-trifluoroethyl 4-cyanophenylcarbamate (CAS 1000932-40-0)
- 5-(2,2,2-Trifluoroethyl)-1H-pyrazol-3-amine (CAS 1001354-48-8)
- 1-(2,2,2-Trifluoroethyl)-1H-pyrazole-5-carboxylic acid (CAS 1006340-71-1)
- 3-Methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-amine (CAS 1006448-59-4)
- Methyl 1-(2,2,2-trifluoroethyl)-1h-pyrazole-4-carboxylate (CAS 1006461-60-4)
- 3-Methyl-1-(2,2,2-trifluoroethyl)-1h-pyrazole-4-carbaldehyde (CAS 1006471-12-0)
- Ethyl 1-(2,2,2-trifluoroethyl)-1H-pyrazole-5-carboxylate (CAS 1006486-11-8)
- 5-Methyl-1-(2,2,2-trifluoroethyl)-1h-pyrazole-3-carboxylic acid (CAS 1006486-45-8)
Recommended Standards
- N,N'-(1,4-Phenylenebis(methanylylidene))bis(3-methylaniline) (CAS 100626-96-8)
- 2-Methyl-1-(methylsulfonyl)-3-nitrobenzene (CAS 90764-86-6)
- Lacidipine-d10 (CAS 1185245-62-8)
- 4-Quinolineboronic Acid Pinacol Ester (CAS 1035458-54-8)
- Di(2-thiazolyl)methanone (CAS 55707-55-6)
- 8-ethyl-2-(propan-2-yl)-1,4-dihydroquinolin-4-one (CAS 1154917-07-3)
- (2R,4R)-1-(tert-butoxycarbonyl)-4-fluoro-2-methylpyrrolidine-2-carboxylic acid (CAS 1447944-59-3)
- 1-[1-(Cyclobutylmethyl)-1H-pyrazol-5-yl]ethan-1-one (CAS 1779952-59-8)
- 3-[(4-fluoro-3-methylphenyl)carbonyl]pyridine (CAS 1182940-73-3)
- Palmitoyl Tetrapeptide-7 (CAS 221227-05-0)
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