Diethyl bis(2-fluorobenzyl)malonate CAS 91319-43-6
| CAS No. | 91319-43-6 |
| Molecular Formula | C21H22F2O4 |
| Molecular Weight | 376.39 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Diethyl bis(2-fluorobenzyl)malonate (CAS 91319-43-6), molecular formula C21H22F2O4 and molecular weight 376.39 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, Diethyl bis(2-fluorobenzyl)malonate (C21H22F2O4) contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 376.39 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), Diethyl bis(2-fluorobenzyl)malonate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H22F2O4 |
| Molecular Weight | 376.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1983 |
| Halogen Content | F-containing |
Related Diethyl Standards
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- Diethyl 2-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]propanedioate (CAS 55810-48-5)
- Diethyl-(6-chloro-2-carbazolyl)methyl-d3 Malonate (CAS 1189473-03-7)
- Diethyl 2-formamido-2-((5-nitro-1H-indol-3-yl)methyl)malonate (CAS 40498-21-3)
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Recommended Standards
- 4-Methoxy-N'-(3-(pyridin-3-yl)-4,5-dihydroisoxazole-5-carbonyl)benzenesulfonohydrazide (CAS 478078-49-8)
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- 4-((4-(N-(4,6-Dimethylpyrimidin-2-yl)sulfamoyl)phenyl)amino)-4-oxobut-2-enoic acid (CAS 910621-63-5)
- N-(5-Nitro-2-thiazolyl)-2-phenylquinoline-4-carboxamide (CAS 349400-40-4)
- 7,8-Dimethyl-2-(pyridin-3-yl)quinoline-4-carbonyl chloride (CAS 1203050-62-7)
- 3-Methyl-1-(2-(phenylthio)ethyl)-1H-pyrazol-5(4H)-one (CAS 55294-10-5)
- n-(2-Bromo-4-fluorobenzyl)-1-(4-methylmorpholin-2-yl)methanamine (CAS 1376352-36-1)
- Fmoc-Gly-Thr(Psi(Me,Me)pro)-OH (CAS 1262308-49-5)
- Omadacycline Impurity 48 (CAS CATO-C4X-285748)
- N-Desmethyl Vandetanib (CAS 338992-12-4)
- 2-(4-(4-Fluorophenyl)piperazin-1-yl)propanoic acid dihydrochloride (CAS 1269151-07-6)
- N-(3-chloro-4-methylphenyl)-2-(4-(pyridin-2-yl)piperazin-1-yl)acetamide (CAS 477333-98-5)
- N-(5-Amino-2-fluorophenyl)-3-chlorobenzamide (CAS 926201-11-8)
- Semaglutide impurity 331 (CAS CATO-C4X-2226231)
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