1-(2-Bromo-6-fluorophenyl)-3-(2-methoxy-5-(trifluoromethyl)phenyl)urea CAS 917389-23-2
| CAS No. | 917389-23-2 |
| Molecular Formula | C15H11BrF4N2O2 |
| Molecular Weight | 407.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies 1-(2-Bromo-6-fluorophenyl)-3-(2-methoxy-5-(trifluoromethyl)phenyl)urea (CAS 917389-23-2), a pharmacopoeial impurity reference standard (molecular formula C15H11BrF4N2O2, MW 407.16 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, 1-(2-Bromo-6-fluorophenyl)-3-(2-methoxy-5-(trifluoromethyl)phenyl)urea is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 407.16 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C15H11BrF4N2O2 |
| Molecular Weight | 407.16 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 2 |
Related Bromo Standards
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Recommended Standards
- (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(2-iodo-6-(methylamino)-9H-purin-9-yl)tetrahydrofuran-3,4-diol (CAS 377774-42-0)
- 3-Chloro-2-({[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanyl}methyl)-5-(trifluoromethyl)pyridine (CAS 321430-84-6)
- Chlorodiethoxy(octadecyl)silane (CAS 33734-79-1)
- 5-[(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-2-iodobenzoic acid (CAS 540513-92-6)
- Vitamin K1 Impurity 21 (CAS 562836-92-4)
- Benserazide impurity 43 (CAS CATO-C4X-142743)
- Landiolol Impurity 26 (CAS CATO-C4X-2621126)
- Neorauflavane (CAS 53734-74-0)
- 5-(3-Methoxybenzyl)-1H-pyrrole-2-carboxylic acid (CAS 1485115-47-6)
- 2-(4-Oxo-6-(piperazin-1-yl)quinazolin-3(4H)-yl)acetic acid (CAS 889958-08-1)
- 1-(((9H-fluoren-9-yl)methoxy)carbonyl)-3-hydroxypyrrolidine-2-carboxylic acid (CAS 1822499-28-4)
- 1-(3-Hydrazinylphenyl)-1H-tetrazole hydrochloride (CAS 847606-72-8)
- 7-Fluoro-2-(pyridin-4-yl)indoline (CAS 592466-00-7)
- Gastric Inhibitory Polypeptide (human) (CAS 100040-31-1)
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