5,7-Difluoro-4,4-dimethyl-3,4-dihydro-2H-[1,3'-biquinolin]-2-one CAS 918646-23-8
| CAS No. | 918646-23-8 |
| Molecular Formula | C20H16F2N2O |
| Molecular Weight | 338.35 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 5,7-Difluoro-4,4-dimethyl-3,4-dihydro-2H-[1,3'-biquinolin]-2-one is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
5,7-Difluoro-4,4-dimethyl-3,4-dihydro-2H-[1,3'-biquinolin]-2-one (CAS 918646-23-8), molecular formula C20H16F2N2O and molecular weight 338.35 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5,7-Difluoro-4,4-dimethyl-3,4-dihydro-2H-[1,3'-biquinolin]-2-one (C20H16F2N2O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5,7-Difluoro-4,4-dimethyl-3,4-dihydro-2H-[1,3'-biquinolin]-2-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H16F2N2O |
| Molecular Weight | 338.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Difluoro Standards
- 5,8-Difluoro-4,4-dimethyl-3,4-dihydro-2H-[1,3'-biquinolin]-2-one (CAS 918646-24-9)
- Benzyl 4,4-difluoro-[1,4'-bipiperidine]-1'-carboxylate (CAS 1233184-79-6)
- (7,8-difluoro-3-hydroxy-1-naphthyl) trifluoromethanesulfonate (CAS 2621935-33-7)
- 1,2-Difluoro-4-((4-(trans-4-propylcyclohexyl)phenyl)ethynyl)benzene (CAS 121118-73-8)
- 2,2-Difluoro-1-(4-methylpiperazin-1-yl)-2-(3-(trifluoromethyl)phenoxy)ethan-1-one (CAS 338792-15-7)
- 1-(2,6-Difluoro-4-iodopyridin-3-yl)-2,2,2-trifluoroethanol (CAS 2863533-01-9)
- 2,2-Difluoro-1-(4-nitrophenyl)ethyl diethyl phosphate (CAS 83567-82-2)
- N-(4,6-Difluoro-3-(2-methoxyethyl)benzo[d]thiazol-2(3H)-ylidene)isoxazole-5-carboxamide (CAS 1006998-87-3)
Recommended Standards
- 5-(Piperidine-1-sulfonyl)-2-(2,2,2-trifluoro-ethoxy)-phenylamine (CAS 556016-29-6)
- 5,7-Dihydroxy-3-(4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl)-4H-chromen-4-one (CAS 68436-47-5)
- 5-(4-(Benzyloxy)benzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione (CAS 477863-06-2)
- 5,7-Dimethyl-2-({[4-(trifluoromethyl)phenyl]methyl}sulfanyl)-[1,2,4]triazolo[1,5-a]pyrimidine (CAS 861208-13-1)
- 2-Methoxy-3-(trifluoromethyl)pyridine-4-acetic acid (CAS 1227581-24-9)
- 1-(2-Bromo-4-methylphenyl)-1H-pyrrole (CAS 142044-85-7)
- 1-Benzyl-5-methylpyrrolidine-2-thione (CAS 127839-92-3)
- Methyl (2s,3s)-3-hydroxy-2-[(triphenylmethyl)amino]butanoate (CAS 728877-98-3)
- 4-(Difluoromethyl)-5-iodo-6-methoxypicolinic acid (CAS 1805544-92-6)
- N4-butyl-6-chloro-N2-methyl-5-(methylthio)pyrimidine-2,4-diamine (CAS 67274-38-8)
- 3-{[3-(benzylcarbamoyl)phenyl]carbamoyl}propanoic acid (CAS 904807-21-2)
- 4-((2-Methylcyclopropyl)methoxy)benzonitrile (CAS 1823953-81-6)
- N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-{[(4-fluorophenyl)methyl]amino}acetamide (CAS 297150-42-6)
- Atrial Natriuretic Polypeptide (4-28), human (CAS 95896-08-5)
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