2-(2-(Benzo[d][1,3]dioxol-5-yl)vinyl)-6-bromoquinazolin-4(3H)-one CAS 922189-65-9
| CAS No. | 922189-65-9 |
| Molecular Formula | C17H11BrN2O3 |
| Molecular Weight | 371.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(2-(Benzo[d][1,3]dioxol-5-yl)vinyl)-6-bromoquinazolin-4(3H)-one (CAS 922189-65-9) is a high-purity analytical reference standard with the molecular formula C17H11BrN2O3 and a molecular weight of 371.18 g/mol.
The molecular framework of 2-(2-(Benzo[d][1,3]dioxol-5-yl)vinyl)-6-bromoquinazolin-4(3H)-one (C17H11BrN2O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H11BrN2O3 |
| Molecular Weight | 371.18 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Benzo Standards
- 2-(Benzo[d][1,3]dioxol-5-yl)-3-((3-methoxyphenyl)amino)-1H-inden-1-one (CAS 1119392-49-2)
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- N-(Benzo[d][1,3]dioxol-5-yl)-2-((1-(4-fluorophenyl)-1H-imidazol-2-yl)thio)acetamide (CAS 688336-83-6)
- N-(Benzo[d][1,3]dioxol-5-yl)-2-methyl-1-phenyl-1H-benzo[d]imidazole-5-carboxamide (CAS 920819-35-8)
- 2-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-N-(4-fluorophenyl)acetamide (CAS 723738-48-5)
- 2-(Benzo[d]oxazol-2-ylthio)-N-((5-(thiophen-2-yl)isoxazol-3-yl)methyl)acetamide (CAS 1207009-75-3)
- 2-((2-(2-(Benzo[d]thiazol-2-ylthio)acetyl)hydrazono)methyl)benzoic acid (CAS 294197-48-1)
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Recommended Standards
- 1-((4,6-Dichloro-1,3,5-triazin-2-yl)amino)anthracene-9,10-dione (CAS 6522-75-4)
- Diethyl (((4-bromophenyl)sulfonyl)methyl)phosphonate (CAS 27691-37-8)
- tert-Butyl 3-bromo-5-methoxy-6-nitro-1H-indole-1-carboxylate (CAS 1822816-83-0)
- Methyl 2-(3-bromo-2-methylphenyl)-7-cyanobenzo[d]oxazole-5-carboxylate (CAS 2459479-71-9)
- 4-(4-Amino-1h-pyrazol-1-yl)butan-1-ol (CAS 1249326-10-0)
- 3-methoxy-1,2-dihydropyrrol-5-one (CAS 69778-83-2)
- 2-Chloro-N-cyclohexylpyridine-3-sulfonamide (CAS 1155912-23-4)
- Hydrocodone Bitartrate CII (100 mg) (CAS 34195-34-1)
- 2-Chloro-4’-nitroacetanilide (CAS 17329-87-2)
- tert-Butyl 2-(4-propylphenoxy)acetate (CAS 1401223-55-9)
- N-(2-amino-6-oxo-3,6-dihydropyrimidin-4-yl)cyanamide (CAS 1255147-74-0)
- 9-Oxa-2-azaspiro[5.5]undecane (CAS 57289-77-7)
- Methyl 2,5-dichloro-3-methoxyisonicotinate (CAS 1305325-16-9)
- (9-D-Asp) Semaglutide X Sodium salt (CAS CATO-CPTD788617)
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