Refametinib CAS 923032-37-5
| CAS No. | 923032-37-5 |
| Molecular Formula | C19H20F3IN2O5S |
| Molecular Weight | 572.34 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Refametinib (C19H20F3IN2O5S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/iodine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies Refametinib (CAS 923032-37-5), a certified reference material (molecular formula C19H20F3IN2O5S, MW 572.34 g/mol) for analytical method development and quality control.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H20F3IN2O5S |
| Molecular Weight | 572.34 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/I-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Recommended Standards
- 1,1,3,3-Tetrakis((trifluoromethyl)sulfonyl)propane (CAS 60805-11-0)
- 923032-38-6 BAY 869766 R enantiomer;RDEA119 R enantiomer;RDEA-119 R enantiomer;BAY 86-9766 R enantiomer (CAS 923032-38-6)
- 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(2-(4-(2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)acetyl)piperazin-1-yl)ethyl)acetamide (CAS 444151-87-5)
- 2-[3-(Benzenesulfonyl)-4-[(2-chloro-6-fluorophenyl)methoxy]phenoxy]-3-chloro-5-(trifluoromethyl)pyridine (CAS 306979-59-9)
- 6-Fluorophthalazine (CAS 1309379-41-6)
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- Ethyl 2-(3-(2-acetylhydrazono)-2-oxoindolin-1-yl)acetate (CAS 624726-26-7)
- 2-(4-Chlorophenyl)-5-phenyl-3-(trifluoromethyl)benzofuran (CAS 821770-02-9)
- 2-((1-Methyl-4-nitro-1h-imidazol-5-yl)amino)ethan-1-ol (CAS 65020-24-8)
- Tau Peptide (277-291) trifluoroacetate salt (CAS 330456-40-1)
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