1-[2-(4-fluorophenyl)-4-methyl-1,3-thiazol-5-yl]ethan-1-one CAS 923701-97-7
| CAS No. | 923701-97-7 |
| Molecular Formula | C12H10FNOS |
| Molecular Weight | 235.28 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1-[2-(4-fluorophenyl)-4-methyl-1,3-thiazol-5-yl]ethan-1-one is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 1-[2-(4-fluorophenyl)-4-methyl-1,3-thiazol-5-yl]ethan-1-one (CAS 923701-97-7), a certified reference material (molecular formula C12H10FNOS, MW 235.28 g/mol) for analytical method development and quality control.
The molecular framework of 1-[2-(4-fluorophenyl)-4-methyl-1,3-thiazol-5-yl]ethan-1-one (C12H10FNOS) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H10FNOS |
| Molecular Weight | 235.28 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related fluorophenyl Standards
- 5-(4-fluorophenyl)-4-methylthiophene-2-carboxamide (CAS 1311587-17-3)
- 2-(((4-Fluorophenyl)thio)methyl)pyrimidin-4-amine (CAS 1466786-32-2)
- 1-(2-(3-Fluorophenyl)-4-methylthiazol-5-yl)ethan-1-one (CAS 879626-93-4)
- 1-[2-(2-fluorophenyl)-4-methyl-1,3-thiazol-5-yl]ethan-1-one (CAS 842115-55-3)
- 2-(4-Fluorophenyl)-2,6-dihydro-4H-thieno[3,4-c]pyrazol-3-amine (CAS 865546-43-6)
- 5-(2-Fluorophenyl)-2,4-dihydro-4-(2-propen-1-yl)-3H-1,2,4-triazole-3-thione (CAS 694461-61-5)
- 5-(4-Fluorophenyl)-N-methylthiophene-2-carboxamide (CAS 338793-87-6)
- N-(2-fluorophenyl)-2-(thiophen-2-yl)acetamide (CAS 335204-10-9)
Recommended Standards
- 1-[2-(4-Nitrophenyl)ethyl]piperazine (CAS 91098-69-0)
- 1,3-Diphenyl-1h-pyrazol-4-amine (CAS 216854-39-6)
- 1-[3-(dimethylamino)propyl]-6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (CAS 40859-37-8)
- 1,1'-(4-Amino-6-hydroxy-5-propyl-1,3-phenylene)bis(ethan-1-one) (CAS 79324-47-3)
- 2-Carboxy 3-Hydroxy Madol Methyl Ester-d5 (1.0mg/ml in Acetonitrile) (CAS 853904-67-3)
- Methyl 3-(2H-1,3-benzodioxol-5-yl)-5-methoxybenzoate (CAS 1820618-35-6)
- 5-Bromo-2,4-bis(trifluoromethyl)pyridine (CAS 1099598-05-6)
- 2-(Chloromethyl)-6-(4-methoxyphenyl)thieno[3,2-d]pyrimidin-4(1h)-one (CAS 875156-68-6)
- (2-Cyano-4-morpholinophenyl)boronic acid (CAS 2225179-08-6)
- 4-(Dimethylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid (CAS 1082147-20-3)
- 6-Chloro-3-methyl-1H-indazole (CAS 55774-25-9)
- 2-Methoxy-N-methyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (CAS 2377607-01-5)
- (R)-2-(isoquinolin-1-yl)-4-neopentyl-4,5-dihydrooxazole (CAS 2415160-72-2)
- Tetrapeptide-3 (CAS 827306-97-8)
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