Ethyl 3-(chlorosulfonyl)-4-methylbenzoate CAS 924871-96-5
| CAS No. | 924871-96-5 |
| Molecular Formula | C10H11ClO4S |
| Molecular Weight | 262.71 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Ethyl 3-(chlorosulfonyl)-4-methylbenzoate (C10H11ClO4S) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Ethyl 3-(chlorosulfonyl)-4-methylbenzoate (CAS 924871-96-5), molecular formula C10H11ClO4S and molecular weight 262.71 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H11ClO4S |
| Molecular Weight | 262.71 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 1 |
Related Ethyl Standards
- Methyl 3-(chlorosulfonyl)-4,5-dimethylbenzoate (CAS 1156634-80-8)
- 1-(3'-Chlorosulfonyl-4'-methoxyphenyl)-1-propanone-methyl-d3 1189984-41-5 (CAS 1189984-41-5)
- Ethyl 2-(3-(chlorosulfonyl)phenyl)acetate (CAS 1190373-83-1)
- Methyl 2-(chlorosulfonyl)-5-ethylbenzoate (CAS 1247825-38-2)
- 4-(Chlorosulfonyl)phenyl isobutyrate (CAS 1315367-19-1)
- Ethyl 2-(chlorosulfonyl)-6-methylbenzoate (CAS 133742-97-9)
- Ethyl 2-[2-(chlorosulfonyl)phenyl]acetate (CAS 1342174-62-2)
- Benzyl 3-(chlorosulfonyl)propanoate (CAS 1394041-79-2)
Recommended Standards
- Ethyl 2-chloro-4-(methylsulfonyl)benzoate (CAS 702672-93-3)
- Ethyl 4-[(chlorosulfonyl)methyl]benzoate (CAS 446847-82-1)
- Ethyl 2-(2-chloroacetamido)-4-methylthiazole-5-carboxylate (CAS 6125-37-7)
- Ethyl 5-(chlorosulfonyl)-2-methylbenzoate (CAS 924859-48-3)
- Methyl (2-cyanophenyl)carbamate (CAS 98879-62-0)
- Ethyl 5,6-dichloro-2-(3-iodophenyl)pyrimidine-4-carboxylate (CAS 1956380-69-0)
- 2,8-Diethynyl-5,5-difluoro-1,3,7,9,10-pentamethyl-5H-4l4,5l4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinine (CAS 1394861-86-9)
- (5-Isobutyl-1,2,4-oxadiazol-3-yl)methanamine hydrochloride (CAS 1609395-28-9)
- N-Biotin-N-bis(PEG4-acid) (CAS 1964503-35-2)
- 2-(4-Butoxybenzoyl)oxazole (CAS 898760-23-1)
- 4-chloro-N'-(4,5-dihydronaphtho[1,2-b]thiophen-2-ylcarbonyl)benzenesulfonohydrazide 477888-02-1 KS-000034L1 (CAS 477888-02-1)
- 1-Bromo-3-(2-nitroethyl)benzene (CAS 155988-06-0)
- 1-Isopropyl-N-(1-methylpiperidin-4-yl)piperidin-4-amine (CAS 1042534-95-1)
- Ephrin-A2-Selective YSA-Peptide (CAS 532441-10-4)
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