Estradiol Impurity N2 CAS 92817-10-2
| CAS No. | 92817-10-2 |
| Molecular Formula | C18H23FO2 |
| Molecular Weight | 290.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 290.37 g/mol gives Estradiol Impurity N2 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Estradiol Impurity N2 (CAS 92817-10-2, C18H23FO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, a hydroxyl group, an ether linkage, fluorine substitution, Estradiol Impurity N2 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 290.37 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Estradiol Impurity N2 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H23FO2 |
| Molecular Weight | 290.37 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1983 |
| Halogen Content | F-containing |
Related Estradiol Standards
- Estradiol Impurity 10 (CAS 1229-24-9)
- Estradiol Impurity 11 (CAS 3583-03-7)
- Estradiol Valerate Impurity 12 (CAS 10582-53-3)
- Estradiol 3-Methyl Ether (CAS 1035-77-4)
- Estradiol Hemihydrate EP Impurity C (CAS 6171-48-8)
- Estradiol Impurity 28 (CAS 3597-38-4)
- Estradiol Impurity 29 (CAS CATO-C4X-163629)
- Estradiol USP Related Compound C (CAS 571-92-6)
Recommended Standards
- Dimethyl 2-(7-fluoroheptyl)-2-isopropylmalonate (CAS 6863-42-9)
- N-(3-(2-Methoxyethyl)-6-methylbenzo[d]thiazol-2(3H)-ylidene)cyclopropanecarboxamide (CAS 1006269-61-9)
- 4'-Methyl-N2-(pyrimidin-2-yl)-[4,5'-bithiazole]-2,2'-diamine (CAS 315705-10-3)
- 5-(Phenylmethyl)-3-[(tetrahydro-2-furanyl)methyl]-2-thioxo-4-imidazolidinone (CAS 1008698-17-6)
- Scopolamine Impurity 7 (CAS 76822-34-9)
- Atogepant Impurity 30 (CAS 52011-50-4)
- Pidotimod Impurity 12 (CAS 135124-63-9)
- 2-(3'-Chloro-[1,1'-biphenyl]-4-yl)aceticacid (CAS 5001-94-5)
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- 3-((Benzyloxy)methyl)-2,2-dimethylcyclobutan-1-one (CAS 1353586-60-3)
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