2-(2-Chloroacetyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2h)-one CAS 929972-54-3
| CAS No. | 929972-54-3 |
| Molecular Formula | C8H6ClN3O2 |
| Molecular Weight | 211.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-(2-Chloroacetyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2h)-one (CAS 929972-54-3), molecular formula C8H6ClN3O2 and molecular weight 211.61 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 2-(2-Chloroacetyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2h)-one (C8H6ClN3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 211.61 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 2-(2-Chloroacetyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2h)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H6ClN3O2 |
| Molecular Weight | 211.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloroacetyl Standards
- 3-(2-Chloroacetyl)benzo[d]oxazol-2(3H)-one (CAS 95923-44-7)
- 6-(2-Chloroacetyl)benzo[d]oxazol-2(3H)-one (CAS 54903-10-5)
- n-[4-(2-chloroacetyl)phenyl]-n-methylformamide (CAS 1152591-86-0)
- 4'-(Chloroacetyl)-acetanilide (CAS 140-49-8)
- N-(2-Chloroacetyl)-2-methylbenzamide (CAS 1415562-56-9)
- Methyl 3-(2-chloroacetyl)benzoate (CAS 177328-89-1)
- [4-(2-chloroacetyl)phenyl]urea (CAS 861520-97-0)
- 2-[(Chloroacetyl)amino]benzamide (CAS 21721-78-8)
Recommended Standards
- 1-(2-Amino-6-chloro-9H-purin-9-yl)ethanone (CAS 470483-92-2)
- 2-(3-Chloro-2H-pyrazolo[3,4-b]pyridin-2-yl)acetic acid (CAS 918484-83-0)
- 4-(5-(Chloromethyl)-1,2,4-oxadiazol-3-yl)pyridine 1-oxide (CAS 1936392-58-3)
- 2-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)acetic acid (CAS 64068-07-1)
- 3-Iodo-6-methoxy-1H-pyrrolo[3,2-b]pyridine (CAS 1190323-03-5)
- N-(2-Isobutyryl-1,2,3,4-tetrahydroisoquinolin-7-yl)-3,4,5-trimethoxybenzamide (CAS 955736-95-5)
- (2R,3R,4S,5R)-2-(6-Amino-8-((4-chlorophenyl)thio)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (CAS 85352-87-0)
- 4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid (CAS 1000340-36-2)
- (2-Bromo-5-methylthiazol-4-yl)methanamine hydrobromide (CAS 1956322-71-6)
- 6-amino-2-ethyl-2,3-dihydro-1H-isoindol-1-one (CAS 1234616-17-1)
- 2-((2-Hydroxyethyl)(isopropyl)amino)-1-(thiazol-2-yl)ethanone (CAS 1353976-64-3)
- 2-(Tetrahydro-2-furanylmethoxy)-1-propanamine (CAS 883537-85-7)
- 3-Methyl-1-(pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine-5-carboxylic acid (CAS 926260-09-5)
- Semaglutide impurity 208 (CAS CATO-C4X-2226208)
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