2-(2,5-Difluorophenyl)pyrimidine-5-carboxylic acid CAS 933988-75-1
| CAS No. | 933988-75-1 |
| Molecular Formula | C11H6F2N2O2 |
| Molecular Weight | 236.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(2,5-Difluorophenyl)pyrimidine-5-carboxylic acid.
2-(2,5-Difluorophenyl)pyrimidine-5-carboxylic acid (CAS 933988-75-1), molecular formula C11H6F2N2O2 and molecular weight 236.17 g/mol, is a CATO reference standard with documented purity and traceability.
2-(2,5-Difluorophenyl)pyrimidine-5-carboxylic acid (C11H6F2N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 2-(2,5-Difluorophenyl)pyrimidine-5-carboxylic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C11H6F2N2O2 |
| Molecular Weight | 236.17 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Difluorophenyl Standards
- 6-(2,4-Difluorophenyl)pyrimidine-4-carboxylic acid (CAS 1207723-93-0)
- 2-(2,3-Difluorophenyl)-1H-imidazole-4,5-dicarbaldehyde (CAS 1268385-46-1)
- 2-(3,4-Difluorophenyl)pyrimidine-5-carboxylic acid (CAS 1274527-32-0)
- 2-(3,5-Difluorophenyl)pyrimidine-5-carboxylic acid (CAS 933988-73-9)
- Ethyl 2-(2,4-difluorophenyl)-2,2-difluoroacetate (CAS 1228957-05-8)
- Ethyl 2-(2,5-difluorophenyl)-2,2-difluoroacetate (CAS 1343850-82-7)
- Ethyl 2-(3,4-Difluorophenyl)-2,2-difluoroacetate (CAS 73789-95-4)
- Ethyl 2-(3,5-difluorophenyl)-2,2-difluoroacetate (CAS 208259-49-8)
Recommended Standards
- 1-(3-(Trifluoromethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)ethan-1-one (CAS 681470-19-9)
- Ethyl 4,4-difluoro-3-oxo-2-(ureidomethylene)butanoate (CAS 1824838-67-6)
- 2,4-Dimethylquinoline-8-selenol (CAS 478960-97-3)
- 3-bromo-1-benzothiophen-7-amine (CAS 1638771-86-4)
- Methyl 4-bromo-3-fluoro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrole-2-carboxylate (CAS 2916880-51-6)
- 4-[4-(Aminomethyl)-1-methyl-3-pyrazolyl]benzonitrile Hydrochloride (CAS 1461707-38-9)
- Noroxycodone-d3 (CAS 1007844-32-7)
- 2-(Chloromethyl)-1,3-thiazole hydrochloride (CAS 71670-79-6)
- 1,2-Difluoro-4-isopropylbenzene (CAS 84564-75-0)
- 1-(3,4-Dichlorophenyl)butan-1-amine hydrochloride (CAS 90944-01-7)
- 4-Cyclopropoxy-3-isopropoxypicolinonitrile (CAS 1243289-66-8)
- 5-Amino-4-bromo-2-fluorobenzonitrile (CAS 893615-28-6)
- N-(5-(tert-Butyl)-4-((6-cyclopentyl-4-hydroxy-6-(4-hydroxyphenethyl)-2-oxo-5,6-dihydro-2H-pyran-3-yl)thio)-2-methylphenyl)benzenesulfonamide (CAS 263842-68-8)
- (Leu31,Pro3?)-Neuropeptide Y (human, rat) trifluoroacetate salt (CAS 132699-73-1)
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