3-(4-Aminophenyl)-6,7-difluoroquinazoline-2,4(1H,3H)-dione hydrochloride CAS 936500-99-1

Purity 97%+In StockPharmaceutical Standards
CAS No.936500-99-1
Molecular FormulaC14H9F2N3O2
Molecular WeightN/A
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

3-(4-Aminophenyl)-6,7-difluoroquinazoline-2,4(1H,3H)-dione hydrochloride CAS 936500-99-1 chemical structure

Description

The occurrence of 3-(4-Aminophenyl)-6,7-difluoroquinazoline-2,4(1H,3H)-dione hydrochloride is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

3-(4-Aminophenyl)-6,7-difluoroquinazoline-2,4(1H,3H)-dione hydrochloride (CAS 936500-99-1), molecular formula C14H9F2N3O2HCl and molecular weight 325.70 g/mol, is a CATO reference standard with documented purity and traceability.

3-(4-Aminophenyl)-6,7-difluoroquinazoline-2,4(1H,3H)-dione hydrochloride (C14H9F2N3O2HCl) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 3-(4-Aminophenyl)-6,7-difluoroquinazoline-2,4(1H,3H)-dione hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC14H9F2N3O2 HCl
Molecular Weight325.70 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep sealed and dry
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)10.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1987
Halogen ContentF/Cl-containing
Nitrogen Atoms3

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