(2E)-3-(2-chloro-4-ethoxy-5-methoxyphenyl)acrylic acid CAS 937599-16-1
| CAS No. | 937599-16-1 |
| Molecular Formula | C12H13ClO4 |
| Molecular Weight | 256.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(2E)-3-(2-chloro-4-ethoxy-5-methoxyphenyl)acrylic acid (CAS 937599-16-1), molecular formula C12H13ClO4 and molecular weight 256.68 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (2E)-3-(2-chloro-4-ethoxy-5-methoxyphenyl)acrylic acid (C12H13ClO4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (2E)-3-(2-chloro-4-ethoxy-5-methoxyphenyl)acrylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H13ClO4 |
| Molecular Weight | 256.68 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
Related E Standards
- Ethyl 3-(5-chloro-2-methoxyphenyl)-3-oxopropanoate (CAS 104029-20-1)
- 7-Chloro-2-phenyl-4H-chromen-4-one (CAS 1148-48-7)
- 1-Chloro-2-methylanthracene-9,10-dione (CAS 129-35-1)
- Ethyl 2-(5-chloro-2-ethoxyphenyl)-2-oxoacetate (CAS 1368208-35-8)
- Ethyl 2-(3-chloro-4-ethoxyphenyl)-2-oxoacetate (CAS 1443324-59-1)
- 1-(5-Chloro-2-methoxyphenyl)-3-hydroxycyclobutane-1-carboxylic acid (CAS 1490613-66-5)
- 5-(5-Chloro-2-methoxyphenyl)-5-oxopentanoic acid (CAS 162930-56-5)
- 4-Chloro-2-phenyl-1H-indene-1,3(2H)-dione (CAS 16707-79-2)
Recommended Standards
- 2-(3-Chlorophenyl)-4H-chromen-4-one (CAS 1849-61-2)
- (2E)-3-(3-chloro-4-ethoxy-5-methoxyphenyl)acrylic acid (CAS 749920-19-2)
- Ethyl 8-(chloromethyl)-4H-benzo[d][1,3]dioxine-6-carboxylate (CAS 175205-83-1)
- (E)-3-(3,4,5-Trimethoxyphenyl)acryloyl chloride (CAS 89652-61-9)
- 3-Fluoro-2-iodo-1-naphthonitrile (CAS 2629318-43-8)
- (1R,3R,4S)-2-[(tert-butoxy)carbonyl]-2-azabicyclo[2.2.1]heptane-3-carboxylic Acid (CAS 134877-63-7)
- Bis(4-chlorophenyl)diselenide (CAS 20541-49-5)
- 5-(2-Methylpyrimidin-4-yl)furan-2-carboxylic acid (CAS 1399655-00-5)
- 4-Amino-5-cyano-3-(difluoromethyl)pyridine-2-sulfonyl chloride (CAS 1806791-34-3)
- 2-Methylchromeno[2,3-e]isoindole-1,3,6(2H)-trione (CAS 92461-62-6)
- ((1R,2S)-2-methyl-2-(methylamino)cyclohexyl)methanol hydrochloride (CAS 1212377-79-1)
- 2-(((2,2-Dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl)amino)benzonitrile (CAS 1020252-22-5)
- Landiolol Impurity 63 (CAS CATO-C4X-263163)
- Acetyl Dipeptide-1 (CAS 196604-48-5)
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