2-(3-Fluoro-4-(trifluoromethyl)phenyl)thiazole-4-carboxylic acid CAS 937602-43-2
| CAS No. | 937602-43-2 |
| Molecular Formula | C11H5F4NO2S |
| Molecular Weight | 291.22 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-(3-Fluoro-4-(trifluoromethyl)phenyl)thiazole-4-carboxylic acid is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-(3-Fluoro-4-(trifluoromethyl)phenyl)thiazole-4-carboxylic acid (CAS 937602-43-2) is a high-purity analytical reference standard with the molecular formula C11H5F4NO2S and a molecular weight of 291.22 g/mol.
The molecular framework of 2-(3-Fluoro-4-(trifluoromethyl)phenyl)thiazole-4-carboxylic acid (C11H5F4NO2S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2-(3-Fluoro-4-(trifluoromethyl)phenyl)thiazole-4-carboxylic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C11H5F4NO2S |
| Molecular Weight | 291.22 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Fluoro Standards
- 2-(5-Fluoro-2-nitrophenoxy)-2-phenylacetic acid (CAS 1016504-23-6)
- 4'-Fluoro-3'-methoxy-5-nitro-[1,1'-biphenyl]-3-carboxylic acid (CAS 1261967-46-7)
- 3'-Fluoro-4'-methoxy-5-nitro-[1,1'-biphenyl]-3-carboxylic acid (CAS 1261976-03-7)
- (3-Fluoro-5-nitro-benzyl)-phosphonic acid diethyl ester (CAS 1208078-45-8)
- 2-((2-Fluoro-5-(trifluoromethyl)phenyl)carbamoyl)cyclopropane-1-carboxylic acid (CAS 1024222-29-4)
- (2-(2-Fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methanol (CAS 317319-36-1)
- (2-(3-Fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methanol (CAS 317319-27-0)
- 5-Fluoro-2-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)-6-methylpyrimidin-4(3H)-one (CAS 1823183-31-8)
Recommended Standards
- 1-Methyl-4-nitro-N-(3-nitrophenyl)-1H-imidazole-5-carboxamide (CAS 345616-71-9)
- 2-(Cyclohex-1-en-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole (CAS 2096336-87-5)
- (S)-2-acetamido-3-(4-(trifluoromethoxy)phenyl)propanoic acid (CAS 500912-21-0)
- 2,3,5,6-Tetrafluoro-4-(phenylsulfonyl)pyridine (CAS 23449-67-4)
- trans-4-[(Dimethylamino)methyl]cyclohexanamine dihydrochloride (CAS 1356954-01-2)
- 4-(Difluoromethyl)-3-hydroxy-6-methylpicolinoyl chloride (CAS 1804861-46-8)
- 2-(1-Methyl-5-nitro-1H-imidazol-2-yl)-5-(propylthio)-1,3,4-thiadiazole (CAS 207236-20-2)
- 7-Fluoro-4,4-dimethyl-3,4-dihydro-1H-quinolin-2-one (CAS 676116-80-6)
- tert-Butyl 4,4-difluorobut-2-enoate (CAS 1909358-86-6)
- 2-(3-chloro-1H-1,2,4-triazol-1-yl)acetic acid (CAS 586337-85-1)
- 4-(Methoxycarbonyl)-5-methyl-1h-pyrazole-3-carboxylic acid (CAS 198135-11-4)
- 3-(m-Tolyl)thiophene (CAS 16938-72-0)
- Dimethyl 2-((2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)amino)fumarate (CAS 60458-95-9)
- Galanin-Like Peptide (rat) trifluoroacetate salt (CAS 245114-97-0)
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