2-[3-cyclopropyl-4-(difluoromethyl)-6-(4-fluorophenyl)-1h-pyrazolo[3,4-b]pyridin-1-yl]acetic acid CAS 937607-28-8
| CAS No. | 937607-28-8 |
| Molecular Formula | C18H14F3N3O2 |
| Molecular Weight | 361.32 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-[3-cyclopropyl-4-(difluoromethyl)-6-(4-fluorophenyl)-1h-pyrazolo[3,4-b]pyridin-1-yl]acetic acid (C18H14F3N3O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
2-[3-cyclopropyl-4-(difluoromethyl)-6-(4-fluorophenyl)-1h-pyrazolo[3,4-b]pyridin-1-yl]acetic acid (CAS 937607-28-8), molecular formula C18H14F3N3O2 and molecular weight 361.32 g/mol, is a CATO reference standard with documented purity and traceability.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-[3-cyclopropyl-4-(difluoromethyl)-6-(4-fluorophenyl)-1h-pyrazolo[3,4-b]pyridin-1-yl]acetic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H14F3N3O2 |
| Molecular Weight | 361.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related cyclopropyl Standards
- 2-[3-cyclopropyl-6-phenyl-4-(trifluoromethyl)-1h-pyrazolo[3,4-b]pyridin-1-yl]acetic acid (CAS 937606-06-9)
- Ethyl 2-(3-cyclopropyl-4-(difluoromethyl)-6-(furan-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetate (CAS 1018050-88-8)
- 2-(3-Cyclopropyl-4-(difluoromethyl)-6-(1,3-dimethyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid (CAS 1006445-13-1)
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Recommended Standards
- 1-Bromo-4-((4-(heptan-4-yl)phenoxy)methyl)benzene (CAS 2007917-46-4)
- (2E)-3-(Dimethylamino)-2-[(E)-5-[3-(trifluoromethyl)phenoxy]pyridine-2-carbonyl]prop-2-enenitrile (CAS 866152-31-0)
- 3-{4-[(2E)-3-(dimethylamino)prop-2-enoyl]phenoxy}-5-(trifluoromethyl)pyridine-2-carbonitrile (CAS 338959-77-6)
- 2-(2-Isobutyl-4-(trifluoromethyl)imidazo[1,2-a][1,8]naphthyridin-8-yl)-1,3,4-oxadiazole (CAS 1431425-66-9)
- 2-(1-Piperidinyl)benzyl Alcohol (CAS 87066-94-2)
- 1-Cyclohexyl-1-phenyl-3-(pyrrolidin-1-yl)propan-1-ol hydrochloride (CAS 30953-84-5)
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- (-)-10-Camphorsulfonimine (3aS)-(-)-4,5,6,7-Tetrahydro-8,8-dimethyl-3H-3a,6-methano-2,1-benzisothiazole 2,2-Dioxide (7S)-(-)-10,10-Dimethyl-3-thia-4-azatricyclo[5.2.1.0(1,5)]dec-4-ene 3,3-Dioxide 60886-80-8 C1393 (CAS 60886-80-8)
- 2-Chloro-1-methoxy-4-methylbenzene (CAS 22002-44-4)
- 2-Chloro-N-(cyclohexylcarbamoyl)acetamide (CAS 16467-50-8)
- 4-(5-Amino-4H-1,2,4-triazol-3-YL)-2-chlorophenol (CAS 1016534-61-4)
- N-(4-Hydroxybenzyl)acetamide (CAS 34185-04-1)
- 3,7-Bis(ethylamino)-2,8-dimethylphenoxazin-5-ium perchlorate (CAS 41830-81-3)
- Fibrinopeptide A, human TFA (CAS 61533-47-9)
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