N-(5-Chloro-2-methoxyphenyl)-2-(6-methyl-2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)acetamide CAS 938948-72-2
| CAS No. | 938948-72-2 |
| Molecular Formula | C18H22ClN3O4 |
| Molecular Weight | 379.84 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-(5-Chloro-2-methoxyphenyl)-2-(6-methyl-2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)acetamide.
N-(5-Chloro-2-methoxyphenyl)-2-(6-methyl-2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)acetamide (CAS 938948-72-2) is a high-purity analytical reference standard with the molecular formula C18H22ClN3O4 and a molecular weight of 379.84 g/mol.
Structurally, N-(5-Chloro-2-methoxyphenyl)-2-(6-methyl-2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)acetamide (C18H22ClN3O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 379.84 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N-(5-Chloro-2-methoxyphenyl)-2-(6-methyl-2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)acetamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H22ClN3O4 |
| Molecular Weight | 379.84 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related N Standards
- Ethyl 4-(2-chloro-3-fluorophenyl)-6-methyl-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate (CAS 2007949-87-1)
- Ethyl 4-(2-chloro-4-fluorophenyl)-6-methyl-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate (CAS 247037-78-1)
- N-(5-Chloro-2-methoxyphenyl)-1-(3,4-dimethylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (CAS 890885-18-4)
- 2-(4-(5-Chloro-2-methylphenyl)piperazin-1-yl)-N-(2,4-difluorophenyl)acetamide (CAS 885427-46-3)
- 2-Chloro-N-(2-(3-(furan-2-yl)-6-oxopyridazin-1(6H)-yl)ethyl)benzenesulfonamide (CAS 946340-47-2)
- 3-Chloro-4-(2,5-dioxo-3-(o-tolyl)imidazolidin-1-yl)benzenesulfonamide (CAS 65513-52-2)
- 3-(7-Chloro-1-(methylthio)-5-oxo-[1,2,4]triazolo[4,3-a]quinazolin-4(5H)-yl)-N-isopropylpropanamide (CAS 1115967-07-1)
- (5E)-5-({3-chloro-4-[(4-fluorophenyl)methoxy]phenyl}methylidene)-2-sulfanylidene-1,3-thiazolidin-4-one (CAS 297150-44-8)
Recommended Standards
- Vonoprazan Impurity C295 (CAS 928325-68-2)
- n-(2-(1h-Indol-3-yl)ethyl)-n-(3-(2-chlorophenyl)-5-methylisoxazol-4-yl)formamide (CAS 920623-24-1)
- Vonoprazan Impurity 242 (CAS CATO-C4X-1020242)
- Bisacodyl Impurity 23 (CAS CATO-C4X-203723)
- 7-(2-Fluorophenyl)-1,4-thiazepane 1,1-dioxide hydrochloride (CAS 2097936-37-1)
- N-(2-((tert-butyldimethylsilyl)oxy)ethyl)oxetan-3-amine (CAS 1616924-64-1)
- 4-(2-(6-Methyl-1H-benzo[d]imidazol-2-yl)ethyl)aniline (CAS 883541-99-9)
- 1-(2-Bromophenyl)cyclobutanecarbonitrile (CAS 28049-62-9)
- Fmoc-d-2-indanylglycine (CAS 205526-40-5)
- Idarubicin Isomer (CAS 58957-93-0)
- 2-Methoxy-6-(trifluoromethyl)pyridine-3-carbonitrile (CAS 935519-13-4)
- Ethyl 2-amino-6-fluoro-3-nitrobenzoate (CAS 150368-37-9)
- Ambroxol Impurity 21 (CAS CATO-C4X-108521)
- Des-Gln24-Tirzepatide (CAS CATO-CPTD788949)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com