Diethyl 2-((5-bromo-1H-indol-3-yl)methylene)malonate CAS 93941-03-8
| CAS No. | 93941-03-8 |
| Molecular Formula | C16H16BrNO4 |
| Molecular Weight | 366.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Diethyl 2-((5-bromo-1H-indol-3-yl)methylene)malonate.
Diethyl 2-((5-bromo-1H-indol-3-yl)methylene)malonate (CAS 93941-03-8), molecular formula C16H16BrNO4 and molecular weight 366.21 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution, Diethyl 2-((5-bromo-1H-indol-3-yl)methylene)malonate is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 366.21 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Diethyl 2-((5-bromo-1H-indol-3-yl)methylene)malonate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H16BrNO4 |
| Molecular Weight | 366.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1983 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Diethyl Standards
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- Diethyl (6-Chloro-2-indolylmethyl)formamido-malonate (CAS 1076199-98-8)
- diethyl 2-(acetylamino)-2-[4-(methoxycarbonyl)benzyl]malonate (CAS 109564-46-7)
- Diethyl 7-benzoylindolizine-1,3-dicarboxylate (CAS 853319-59-2)
- Diethyl (3,3-bis(trifluoromethyl)-2-azabicyclo[2.2.1]hept-5-en-2-yl)phosphonate (CAS 213257-98-8)
- Diethyl 5-hydroxy-6-iodopyridine-3,4-dicarboxylate, 97% (CAS 1421827-31-7)
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Recommended Standards
- 7-(4-Bromophenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ol (CAS 220835-18-7)
- Ethyl 3-(benzyloxy)-5-bromo-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxylate (CAS 2387599-96-2)
- 4-Bromo-2-[(1E)-[(3,5-dimethoxyphenyl)imino]methyl]-6-methoxyphenol (CAS 477848-22-9)
- Methyl 2-(3-(5-(4-bromophenyl)furan-2-yl)propanamido)acetate (CAS 853331-26-7)
- 4,4-Dimethylpiperidine-2-carboxylic acid (CAS 137734-86-2)
- 3-bromoquinoline-6-carboxylic acid (CAS 205114-14-3)
- 4-[(4-Bromophenyl)(p-tolyl)amino]benzaldehyde (CAS 733744-98-4)
- 6-Methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline-2,4-diol (CAS 1320288-29-6)
- 3-Cyclopropyl-1-(4-fluorophenyl)-6-oxo-3a,6,7,7a-tetrahydro-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid (CAS 1160246-24-1)
- 6-bromo-4-chloro-1H-imidazo[4,5-c]pyridine (CAS 1638767-93-7)
- 5-Chloromethyl-3-(3-methoxy-phenyl)-[1,2,4]oxadiazole (CAS 660416-39-7)
- Methyl 1-(4-fluorophenyl)-5-hydroxy-1H-1,2,3-triazole-4-carboxylate (CAS 728024-45-1)
- N-(benzo[d][1,3]dioxol-5-ylmethyl)methanesulfonamide (CAS 184041-99-4)
- Peptide Impurity 13 (CAS CATO-CPTD788813)
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