6-(Trifluoromethoxy)nicotinic Acid CAS 940895-85-2
| CAS No. | 940895-85-2 |
| Molecular Formula | C7H4F3NO3 |
| Molecular Weight | 207.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
6-(Trifluoromethoxy)nicotinic Acid (CAS 940895-85-2) is a high-purity analytical reference standard with the molecular formula C7H4F3NO3 and a molecular weight of 207.11 g/mol.
The molecular framework of 6-(Trifluoromethoxy)nicotinic Acid (C7H4F3NO3) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), 6-(Trifluoromethoxy)nicotinic Acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H4F3NO3 |
| Molecular Weight | 207.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Trifluoromethoxy Standards
- 5-(Trifluoromethoxy)pyridine-2-carboxylic Acid (CAS 102771-66-4)
- 5-(Trifluoromethoxy)pyridine-3-carboxylic acid (CAS 1060815-03-3)
- 3-(Trifluoromethoxy)isonicotinic acid (CAS 1221171-76-1)
- 3-(Trifluoromethoxy)pyridine-2-carboxylic Acid (CAS 1221171-81-8)
- 2-(Trifluoromethoxy)nicotinic acid (CAS 1221171-92-1)
- 2-(Trifluoromethoxy)isonicotinic acid (CAS 1221171-98-7)
- 6-(Trifluoromethoxy)picolinic acid (CAS 1221172-11-7)
- 4-(Trifluoromethoxy)nicotinic acid (CAS 1361495-12-6)
Recommended Standards
- 5-Nitro-2-(trifluoromethyl)pyridin-4-amine (CAS 438564-36-4)
- 6-Hydroxy-2-(trifluoromethyl)nicotinic acid (CAS 862111-58-8)
- 5-Nitro-2-(trifluoromethyl)phenol (CAS 612498-85-8)
- 6-Oxo-5-(trifluoromethyl)-1,6-dihydropyridine-2-carboxylic acid (CAS 855915-13-8)
- Dimethyl 2,6-pyridinedicarboxylate 2,6-Bismethoxycarbonylpyridine 2,6-Dicarbomethoxypyridine 2,6-Dimethyl pyridine-2,6-dicarboxylate Dipicolinic acid dimethyl ester 5453-67-8 (CAS 5453-67-8)
- 2-Ethyl-7-nitro-9H-benzo[e][1,2,4]triazolo[5,1-b][1,3]thiazin-9-ol (CAS 663206-23-3)
- 2H-1,3-benzodioxole-5-sulfonamide (CAS 5279-49-2)
- methyl 4-methoxypentanoate (CAS 818-68-8)
- 5-Bromo-2-methyl-4-nitropyridine-1-oxide, 97% (CAS 62516-08-9)
- 4-Chloro-2-(4-methoxybenzyl)pyrido[3,2-c]pyridazine-3,6(2H,5H)-dione (CAS 2447686-94-2)
- ((3S,4R)-1-Benzyl-4-phenylpyrrolidin-3-yl)methanol (CAS 221141-89-5)
- Ethyl 6-oxo-6-[3-(3-pyrrolinomethyl)phenyl]hexanoate (CAS 898749-80-9)
- tert-Butyl 4-oxo-[1,4'-bipiperidine]-1'-carboxylate (CAS 1185732-60-8)
- D-[Val]10-Semaglutide (CAS CATO-CPTD788630)
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