N-(2-chloro-4-fluorobenzyl)pyridin-2-amine CAS 942852-80-4
| CAS No. | 942852-80-4 |
| Molecular Formula | C12H10ClFN2 |
| Molecular Weight | 236.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
N-(2-chloro-4-fluorobenzyl)pyridin-2-amine (CAS 942852-80-4), molecular formula C12H10ClFN2 and molecular weight 236.67 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution, N-(2-chloro-4-fluorobenzyl)pyridin-2-amine is typically pale yellow to yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 236.67 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H10ClFN2 |
| Molecular Weight | 236.67 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related N Standards
- 4'-Chloro-3-fluoro-4-methoxy-1,1'-biphenyl (CAS 1032507-29-1)
- 5-Chloro-N-(4-fluorobenzyl)pyridin-2-amine (CAS 1036556-38-3)
- 4-Chloro-2-fluoro-1-(phenylmethoxy)benzene (CAS 1044067-73-3)
- 4-Chloro-2'-fluoro-2-methoxy-1,1'-biphenyl (CAS 1214371-26-2)
- 4-Chloro-6-ethyl-2-(2-fluorophenyl)pyrimidine (CAS 1239845-85-2)
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- (5-(4-Chloro-3-fluorophenyl)pyridin-3-yl)methanamine (CAS 1346691-97-1)
- (5-(3-Chloro-2-fluorophenyl)pyridin-3-yl)methanamine (CAS 1346692-08-7)
Recommended Standards
- methyl 7-chloro-4-fluoro-1H-indazole-5-carboxylate (CAS 2489544-28-5)
- N-(2-chloro-6-fluorobenzyl)pyridin-2-amine (CAS 942893-60-9)
- 6-chloro-7-fluoro-quinazoline-2-carboxylic acid (CAS 2306272-16-0)
- 6-Chloro-3-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazine (CAS 1032705-56-8)
- 1-(Piperidin-4-ylsulfonyl)piperidine hydrochloride (CAS 2138171-83-0)
- 3-((4-Chlorophenyl)sulfonyl)-1-(furan-2-ylmethyl)-2-imino-8-methyl-1H-dipyrido[1,2-a:2',3'-d]pyrimidin-5(2H)-one (CAS 606953-66-6)
- 3-(4-Methoxyphenyl)pyrrolidine (CAS 91246-26-3)
- 1-Benzyl-4-cyclopropylpyrrolidine-3-carboxylic acid (CAS 186203-60-1)
- 3-(2-Bromophenyl)-1H-1,2,4-triazol-5-amine (CAS 59301-25-6)
- 1-(5-Methyl-1,2-oxazole-4-carbonyl)piperidine-4-carboxylic acid (CAS 926261-98-5)
- 1-[(3,5-dimethoxyphenyl)methyl]piperazine (CAS 118778-74-8)
- 2-Fluoro-3-methoxy-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid (CAS 2377608-63-2)
- 5-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid (CAS 1095822-69-7)
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