2-Amino-2-(3-chloro-4-hydroxyphenyl)acetic acid CAS 943-31-7
| CAS No. | 943-31-7 |
| Molecular Formula | C8H8ClNO3 |
| Molecular Weight | 201.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Amino-2-(3-chloro-4-hydroxyphenyl)acetic acid.
2-Amino-2-(3-chloro-4-hydroxyphenyl)acetic acid (CAS 943-31-7), molecular formula C8H8ClNO3 and molecular weight 201.61 g/mol, is a CATO reference standard with documented purity and traceability.
2-Amino-2-(3-chloro-4-hydroxyphenyl)acetic acid (C8H8ClNO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Amino-2-(3-chloro-4-hydroxyphenyl)acetic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H8ClNO3 |
| Molecular Weight | 201.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Amino Standards
- 4-Amino-2-chloro-5-methoxybenzoic acid (CAS 1001347-19-8)
- Methyl 2-amino-5-chloro-3-hydroxybenzoate (CAS 1007113-32-7)
- Ethyl 6-amino-5-chloropyrimidine-4-carboxylate (CAS 1097250-86-6)
- (2S)-2-amino-2-(3-chloro-4-hydroxyphenyl)acetic acid (CAS 111266-44-5)
- Methyl 3-amino-5-chloro-6-methylpyrazine-2-carboxylate (CAS 1131-23-3)
- 5-AMino-2-chloro-4-methoxy-benzoic acid (CAS 1143622-07-4)
- methyl 4-amino-3-chloro-2-hydroxybenzoate (CAS 1154415-33-4)
- 2-Amino-3-chloro-4-methoxybenzoic acid (CAS 1180495-74-2)
Recommended Standards
- 2,6-Dimethoxy-3-pyridinecarbonyl chloride (CAS 95383-48-5)
- 2-Amino-4-chloro-3-methoxybenzoic acid (CAS 67303-46-2)
- 2-(Chloromethyl)-1-methoxy-4-nitrobenzene (CAS 93-06-1)
- 2-Amino-5-chloro-3-methoxybenzoic acid (CAS 58026-22-5)
- 4-Amino-3-(tert-butylamino)-2-methylbenzonitrile (CAS 1375069-39-8)
- 4-(1-Isopropyl-1H-pyrrolo-[2,3-c]pyridin-3-yl)pyrimidin-2-ol (CAS 1221153-86-1)
- 1-Benzyl-6-methoxy-1h-indole-2-carboxylic acid (CAS 903159-31-9)
- Ethyl 2-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)acetate (CAS 1823243-43-1)
- 5-Pyrimidinecarbonitrile, 2-(methylamino)- (7CI,8CI,9CI) 5388-28-3 (CAS 5388-28-3)
- 1,1-Bis(1-methyl-1h-pyrazol-4-yl)methanamine (CAS 1479117-62-8)
- Zinc resinate (CAS 9010-69-9)
- Mometasone Furoate Impurity 40 (CAS CATO-C4X-170440)
- Ethyl 4-iodo-5-methyl-1h-pyrazole-3-carboxylate (CAS 1019403-26-9)
- Tau Peptide (295-309) trifluoroacetate salt (CAS 330456-46-7)
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